Functional MRI of diabetic peripheral vascular disease

糖尿病周围血管疾病的功能MRI

• 批准号: 6666919
• 负责人: Ronald A. Meyer
• 金额: $ 14.95万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6666919
• 关键词: bioimaging /biomedical imaging; clinical research; computer program /software; diabetes mellitus; diabetic angiopathy; diagnosis design /evaluation; early diagnosis; exercise; functional magnetic resonance imaging; human subject; infrared spectrometry; medical complication; noninvasive diagnosis; patient oriented research; reactive hyperemia; respiratory oxygenation; striated muscles; ultrasound blood flow measurement; vascular resistance

DESCRIPTION (provided by applicant): Prolonged diabetes is well known to be associated with widespread microvascular and macrovascular defects, including altered vascular reactivity and increased arterial stiffness. This pilot (R21) project will examine if these vascular changes can be detected early in the course of the disease in peripheral muscles using completely non-invasive magnetic resonance imaging (MRI) techniques, combined with simple, low-impact exercise tests. Aim 1 will examine if the transient reflex muscle hyperemia observed in healthy subjects after brief contractions is altered in patients with Type I (n=15) and Type II (n=15) diabetes compared to age/sex/weight matched control subjects (n=30). Hyperemia transients will be measured by oxygenation-sensitive changes in echo-planar MRI signal intensity (blood-oxygenation level dependent (BOLD) effect), as well as by near-infrared spectroscopy and Doppler ultrasound. Aim 2 will examine if analysis of phase-contrast MRI flow waveforms from peripheral arteries before and after exercise can yield a simple, non-invasive index of arterial stiffness in diabetic vs control subjects, Aim 3 will exploit the increase in muscle T2 after exercise as an index of functional oxidative capacity in peripheral muscles of diabetic vs control subjects. The MRI portion of this study will be accomplished during a single-session MRI-exercise test, which could be adapted for routine evaluation of peripheral vascular complications in diabetic patients.

描述（由申请人提供）：众所周知，长时间的糖尿病与广泛的微血管和大血管缺陷有关，包括改变血管反应性和动脉僵硬增加。该试点（R21）项目将检查在外周肌肉中使用完全非侵入性的磁共振成像（MRI）技术的早期在疾病的早期中检测到这些血管变化，并结合了简单的，低功能的运动测试。 AIM 1将检查与年龄/性别/体重匹配的对照组相比，I型（n = 15）和II型（n = 15）糖尿病患者（n = 15）和II型（n = 15）糖尿病患者的短暂收缩后，在健康受试者中观察到的短暂反射肌肉充血。高血症瞬变将通过回声平面MRI信号强度的氧合敏感性变化（血液氧化水平（BOLD）效应）以及近红外光谱和多普勒超声来测量。 AIM 2将检查运动前后对糖尿病控制受试者中动脉刚度的简单，非侵入性指数的相对对比度MRI流动波形的分析，AIM 3将利用肌肉T2的增加，将肌肉T2的增加作为糖尿病对照对受外围肌肉的功能性氧化能力的锻炼后的锻炼。这项研究的MRI部分将在一次课程的MRI练习测试中完成，该测试可以适用于糖尿病患者的外周血管并发症的常规评估。