Physiology of vestibulo-thalamic pathways

前庭丘脑通路的生理学

基本信息

批准号：
6523505
负责人：
Robert A. McCrea
金额：
$ 27.02万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-15 至 2006-08-31
项目状态：
已结题

项目摘要

DESCRIPIION(provided by applicant)Sensory vestibular signals are transformed in the vestibular nuclei aboutn a vartety of ways. The nature of transformation depends on the type of vestibular nucleus neuron and the behavioral context. The goals of proposed studies are 1) to determine the dynamic characteristics and coordinate frame(s) of the angular linear self-motion signals carried by vestibulo-thalamic pathways and 2) to determine how these self-mo about signals change as a function of behavioral context. Single unit recordings will be obtained fi orthodromically identified secondary vestibular neurons that project to the thalamus. The focus will be units whose firing behavior is related to horizontal rotation and/or translation in the horizontal plane. interaction of vestibular signals with visual self-motion signals will be studied by comparing unit response passive movement in the dark with responses evoked in a lighted surround or during viewing of target, different distances. The interaction of vestibular signals with proprioceptive estimates of self-motion wil] studied by comparing unit responses to passive movement in the dark with responses evoked when the hea about held stable in space and the body is moved, or the platform that serves as the support surface is moved. 1 self motion signals produced by vestibulo-thalamic neurons during passive and active movements will compared signals produced during smooth tracking head movements. Different combinations of act rotational and translational head movements will be examined. In some conditions the head will be free move in the plane of the horizontal semicircular canal and in others it will be restrained from moving respect to the body or with respect to the turntable. The results will add to our fundamental understandin about how multimodal sensory signals are integrated in ascending vestibular sensory pathways, and how they modified in different behavioral contexts. Such knowledge should be useful in the development countermeasures for the profound changes in sensory processing of vestibular sensory information in elde people who suffer from a progressive loss of vestibular function.

描述（由申请人提供）感觉前庭信号被转化为前庭核团有多种方式。转型的本质取决于前庭核神经元的类型和行为背景。拟议研究的目标是 1) 确定动态特性以及所携带的角度线性自运动信号的坐标系前庭丘脑通路和 2) 确定这些自我调节信号如何变化作为行为背景的函数。单个单元的录音将获得顺向鉴定的次级前庭神经元投射到丘脑。焦点将是射击行为为与水平面内的水平旋转和/或平移相关。前庭信号与视觉自我运动信号的相互作用将是通过比较黑暗中的单位响应被动运动与响应进行研究在有灯光的环境中或在观察不同距离的目标时诱发。前庭信号与本体感觉估计的相互作用通过比较单位对被动运动的反应来研究自我运动当心在空间和身体中保持稳定时，会引起黑暗的反应移动，或者作为支撑面的平台移动。 1 个人前庭丘脑神经元在被动和主动期间产生的运动信号运动将比较平滑跟踪头部运动期间产生的信号。动作旋转和平移头部运动的不同组合将被检查。在某些情况下，头部可以在平面内自由移动水平半规管和其他它将被限制移动相对于主体或相对于转盘。结果将添加到我们对多模态感觉信号如何产生的基本理解整合到上行前庭感觉通路中，以及它们如何在不同的行为背景。这些知识应该是有用的感官加工深刻变革的发展对策患有进行性痴呆症的老年人的前庭感觉信息前庭功能丧失。