PHYSIOLOGY OF OCULOMOTOR PREMOTOR PATHWAYS

动眼运动前通路的生理学

• 批准号: 2471200
• 负责人: Robert A. McCrea
• 金额: $ 20.72万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2471200
• 关键词: Saimiri; brain electrical activity; cerebellar Purkinje cell; head movements; neural information processing; neuroanatomy; neurons; neurophysiology; semicircular duct; vestibular pathway; vestibuloocular reflex; visual pathways; visual tracking

DESCRIPTION (Adapted from the Investigator's Abstract): The purpose of the research in this proposal is to determine how signal processing in central oculomotor pathways, particularly those related to the vestibulo-ocular reflex (VOR), are modified by active head movements and target distance. The studies proposed will be focused primarily on 1) recording the response properties of identified secondary vestibulo-ocular reflex neurons and neurons in the vestibulo-cerebellum in alert, head free squirrel monkeys and 2) recording from the same cells during combined angular and linear vestibular stimuli and during vergence related gain changes in the VOR. There are three specific aims: 1. The firing behavior of different classes of identified secondary vestibulo-ocular reflex neurons related to the horizontal semicircular canal or to horizontal eye movements will be recorded in head-free monkeys during a variety of different types of head movements, particularly pursuit of moving visual targets. The contribution of neck afferent inputs to the response of the cells during head pursuit will be assessed by passive rotation of the body while fixing the position of the head in space, and by comparing the responses evoked by passive head and neck rotation to passive whole body rotation. The goal of these studies is to determine what signals horizontal vestibulo-ocular reflex neurons generate during active head movements. 2. The firing behavior of secondary vestibulo-ocular reflex neurons during different combinations of angular and linear head acceleration will be studied. The changes in cellular responses associated with near target viewing will be evaluated, and the contribution of different classes of secondary VOR neurons to the parametric gain changes in the VOR will be determined. 3. Single unit recordings will be made from Purkinje cells in the vestibulo-cerebellum using the paradigms described in the first and second aims. Their responses will be studied during different combinations of angular and linear head acceleration, and during parametric gain changes in the AVOR and LVOR related to viewing distance. The results of these studies are expected to increase our knowledge of the neural mechanisms that are utilized to maintain stable, binocular vision of objects at different distances during active and passive head movements.

描述（改编自研究者的摘要）：目的 本提案的研究是确定中央处理器中的信号处理方式 动眼神经通路，特别是与前庭眼相关的通路 反射（VOR），通过主动头部运动和目标距离进行修改。 拟议的研究将主要集中在 1）记录响应 已识别的次级前庭眼反射神经元的特性和 警觉、无头松鼠猴的前庭小脑神经元和 2) 在组合角度和线性期间从相同的细胞进行记录 前庭刺激和聚散期间 VOR 相关增益变化。 具体目标有3个： 1. 不同类别的射击行为 已确定的次级前庭眼反射神经元的相关 水平半规管或水平眼球运动将 在无头猴子中记录了各种不同类型的头部 运动，特别是追求移动的视觉目标。 贡献 头部追踪过程中颈部传入输入对细胞反应的影响 将通过固定位置时身体的被动旋转进行评估 头部在太空中的位置，并通过比较被动头部引起的反应 颈部旋转变为全身被动旋转。 这些研究的目标 确定水平前庭眼反射神经元的信号 在主动头部运动期间产生。 2. 次级的点火行为 前庭眼反射神经元在不同的角度和角度组合下 将研究线性头部加速度。 细胞反应的变化 将评估与近目标观看相关的贡献 不同类别的次级 VOR 神经元对参数增益变化的影响 VOR 中的值将被确定。 3. 单机录音将由 前庭小脑中的浦肯野细胞使用中描述的范例 第一个和第二个目标。 他们的反应将在不同时期进行研究 角加速度和线性头加速度的组合，以及在参数化过程中 AVOR 和 LVOR 的增益变化与观看距离有关。 结果 这些研究预计将增加我们对神经网络的了解 用于维持物体稳定的双眼视觉的机制 在主动和被动头部运动期间在不同距离处。