BRIAN INJURY TRAINING GRANT

布莱恩伤病培训补助金

• 批准号: 6592739
• 负责人: TRACY K. MCINTOSH
• 金额: $ 22.36万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6592739
• 关键词: BRIAN; INJURY; TRAINING; GRANT

DESCRIPTION (provided by applicant): The proposed program will train M.D., Ph.D. and medical student investigators in state-of-the-art techniques to investigate the molecular and cellular mechanisms underlying central nervous system (CNS) injury. The trainees will be: 1) Physicians involved in the University of Pennsylvania Neurosurgical residency-training program, 2) Ph.D. scientists with prior training in molecular biology, or 3) selected medical students who are participating in Penn's unique Clinical Neuroscience Track program. This program will provide background and training in molecular neurobiology and an introduction to CNS disorders where these new techniques can be applied. This program will be a laboratory-based research-training program that includes experience in novel molecular biology techniques in an interactive and supportive setting. The institution has an extensive didactic program in basic and clinical neurosciences, neurodegeneration, CNS injury, and molecular biology including gene therapy, which will be individually designed for each trainee in order to supplement the laboratory experience. Each trainee will design and complete an independent project providing experience in design and analysis of experiments and in the presentation and publication of results. Weekly trainee research seminars and monthly faculty/trainee mini-symposia provide constant interchange and exchange between faculty trainers and trainees. This program will be run by individual faculty trainers who are the leaders in their field at the University of Pennsylvania, representing disciplines such as CNS ischemia and trauma, neurodegenerative diseases, inheritable neurological disorders, demyelinating diseases, epilepsy, neuroanesthesiology, molecular virology, gene therapy, and molecular pharmacology. Each trainee selects one laboratory for the primary research project but will have complete access to the other trainers for advise, technical assistance, and collaboration. Each trainer has independent NIH funding and all have active and internationally-recognized research programs. Core services available within the University of Pennsylvania, Wistar Institute, Children's Seashore House, and the Institute of Human Genome Therapy include protein sequencing, oligonucleotide synthesis, transgenic knock out/ knock in technology, automated DNA sequencing, viral vector construction, and gene therapy techniques. No funding mechanism currently exists at the University of Pennsylvania to support these trainees. The funding of this Brain Injury Training Grant (BITG) application will establish a novel and important infrastructure involving a highly collaborative faculty for the purpose of training future research scientists and clinicians in the state-of-the-art techniques related to an important clinical disease.

描述（由申请人提供）：拟议的项目将培训医学博士、博士。和医学生研究人员使用最先进的技术来研究中枢神经系统（CNS）损伤的分子和细胞机制。学员将是：1）参与宾夕法尼亚大学神经外科住院医师培训计划的医生，2）博士。接受过分子生物学培训的科学家，或 3) 参加宾夕法尼亚大学独特的临床神经科学轨道项目的精选医学生。该计划将提供分子神经生物学的背景和培训，并介绍可以应用这些新技术的中枢神经系统疾病。该计划将是一个基于实验室的研究培训计划，包括在互动和支持性环境中新型分子生物学技术的经验。该机构在基础和临床神经科学、神经退行性疾病、中枢神经系统损伤和分子生物学（包括基因治疗）方面拥有广泛的教学计划，将为每位学员单独设计，以补充实验室经验。每位学员将设计并完成一个独立的项目，提供实验设计和分析以及结果展示和出版方面的经验。每周的实习生研究研讨会和每月的教师/实习生小型研讨会为教师培训师和实习生之间提供了持续的交流和交流。该项目将由宾夕法尼亚大学各自领域的领导者个人教师培训师负责，代表中枢神经系统缺血和创伤、神经退行性疾病、遗传性神经系统疾病、脱髓鞘疾病、癫痫、神经麻醉学、分子病毒学、基因治疗等学科和分子药理学。每位学员为主要研究项目选择一个实验室，但可以完全向其他培训师寻求建议、技术援助和合作。每位培训师都拥有独立的 NIH 资助，并且都拥有活跃且国际认可的研究项目。宾夕法尼亚大学、Wistar 研究所、儿童海滨别墅和人类基因组治疗研究所提供的核心服务包括蛋白质测序、寡核苷酸合成、转基因敲除/敲入技术、自动 DNA 测序、病毒载体构建和基因治疗技术。宾夕法尼亚大学目前没有资助机制来支持这些学员。脑损伤培训补助金 (BITG) 申请的资金将建立一个新颖且重要的基础设施，涉及高度协作的教师，旨在培训未来的研究科学家和临床医生，掌握与重要临床疾病相关的最先进技术。