HEALTH IMPROVEMENT & COST REDUCTION IN ANIMAL FACILITIES

健康改善

• 批准号: 6487045
• 负责人: ABIGAIL L SMITH
• 金额: $ 40.72万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6487045
• 关键词: Helicobacter; Mus musculus; Pasteurella; Pneumocystis carinii; SCID mouse; Staphylococcus aureus; air filtration; air sampling /monitoring; airborne allergen; ammonia; animal care; animal colony; clinical research; communicable disease control; cost effectiveness; enzyme linked immunosorbent assay; epizootiology; germ free condition; human subject; immediate hypersensitivity; nonbiomedical equipment; occupational disease /disorder; occupational health /safety; polymerase chain reaction; tissue /cell culture; work site

DESCRIPTION (Provided by applicant): The overall goal of the proposed studies is to establish environmental conditions that optimize the health of mice used in biomedical research, provide a safe and comfortable workplace, and minimize the costs associated with doing animal-based research. The methods by which the applicants will approach this goal include: (1) determining housing conditions that minimize pathogen transfer, (2) evaluating effects of culling on reproductive success, (3) identifying husbandry and hygiene practices that reduce caretaker exposure to mouse allergen, and (4) instituting workplace activities that may improve the health of animal caretakers. The investigators will first study the capacity of ventilated caging maintained at "neutral" airflow and negatively ventilated changing tables to reduce worker exposure to allergen and to reduce or eliminate transfer of Pasteurella pneumotropica, Helicobacter spp. and Pneumocystis carinii from infected mice to pathogen-free immunocompromised mice. The applicants will determine reproductive success of mice whose litters are culled or not and housed under different ventilation conditions. The efficacy of water, dilute tannic acid, and dilute sodium hypochlorite used to reduce breathing zone allergen levels during bedding changes will be tested. Skin and clothing of caretakers will be sampled for Staphylococcus aureus upon entry into mouse rooms through air or wet showers and for allergen upon exiting the facility through air or wet showers. In an effort to reduce employee workplace injuries, a functional capacity checklist will be developed and will be used to design an employee exercise program. Lastly, a pre-employment Functional Capacity Assessment tool to help slot new hires in positions for which they are physically capable will be used.

描述（由申请人提供）：拟议研究的总体目标 是建立优化所用小鼠健康的环境条件 在生物医学研究中，提供安全舒适的工作场所，并最大程度地减少 与进行基于动物的研究有关的成本。 用的方法 申请人将实现此目标包括：（1）确定住房 最小化病原体转移的条件，（2）评估淘汰的效果 关于生殖成功，（3）确定畜牧业和卫生实践 减少看护人暴露于鼠标过敏原，（4）建立工作场所 可以改善动物看护者健康的活动。 这 调查人员将首先研究维护的通风笼的能力 “中立”气流和否定通风的变化表，以减少工人 暴露于过敏原并减少或消除巴斯德奶酪的转移 肺炎，螺旋杆菌属。和受感染小鼠的肺囊肿 到无病原体免疫功能低下的小鼠。 申请人将确定 小鼠的生殖成功，其垃圾被淘汰是否被拿走并被安置在下面 不同的通风条件。 水的功效，稀释单宁酸， 和稀释的次氯酸钠用于降低呼吸区过敏原水平 在床上用品更换期间将进行测试。 看护人的皮肤和衣服将 通过空气进入鼠标房间后，将金黄色葡萄球菌采样 或湿淋浴，对于过敏到通过空气或湿 淋浴。 为了减少员工工作场所伤害，功能性 容量清单将开发，并将用于设计员工 锻炼计划。 最后，就业前职能能力评估 帮助插槽新员工的工具，他们在身体上有能力 将使用。