CLOTBUST

凝块胸围

• 批准号: 6695780
• 负责人: Andrei V Alexandrov
• 金额: $ 14.34万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6695780
• 关键词: bioimaging /biomedical imaging; brain disorder diagnosis; brain imaging /visualization /scanning; cerebral hemorrhage; computed axial tomography; diagnosis design /evaluation; fibrinolysis; human subject; human therapy evaluation; intravenous administration; patient oriented research; plasminogen activator; stroke; stroke therapy; technology /technique development; ultrasonography

DESCRIPTION (provided by the applicant): The primary specific aims for this pilot Phase II studies are: 1. To determine complete recanalization and early clinical recovery rates in patients treated with intravenous TPA and continuously monitored with an external ultrasound compared to those treated with standard TPA dose alone. 2. To determine if continuous monitoring of TPA infusion with external ultrasound is safe and will not result in higher rates of symptomatic intracerebral hemorrhage compared to controls. 3. Data generated during this Phase II trial will form the basis for a design of a properly powered multicenter Phase III trial.

描述（由申请人提供）：该试点II期研究的主要特定目的 为：1。确定用静脉内TPA治疗的患者的完全再续新化和早期临床回收率，并与外部超声进行不断监测的患者相比 单独使用标准TPA剂量处理。 2。确定与对照组相比，对TPA输注的连续监测是否安全，并且不会导致症状性脑内出血的率更高。 3。在此II阶段试验中产生的数据将构成设计正确的多中心III期试验的基础。