Cortical Reconstruction and Analysis Software

皮质重建和分析软件

• 批准号: 7029816
• 负责人: Dzung L Pham
• 金额: $ 25.31万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-19 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7029816
• 关键词: bioimaging /biomedical imaging; brain disorder diagnosis; brain imaging /visualization /scanning; brain morphology; cerebral cortex; clinical research; computer assisted diagnosis; computer program /software; computer simulation; computer system design /evaluation; diagnosis design /evaluation; human data; magnetic resonance imaging; mathematical model; model design /development

DESCRIPTION (provided by applicant): The goal of this proposal is to develop largely automated and user-friendly software tools for finding and mathematically representing the cerebral cortex in volumetric magnetic resonance (MR) images. These software tools will be made publicly and freely available and will be useful in studies involving 1) the development of a description of normal versus diseased cortical geometry, 2) landmark generation for deformable atlas registration, 3) statistical analyses of structure/function relationships, and 4) characterization of morphological changes in aging and disease. The algorithms that will form the basis for the developed software tools stem from our own research work on cortical reconstruction and analysis. We propose five specific aims: 1) incorporate the core volumetric processing algorithms into MIPAV, a commercial-quality but freely available software package developed at NIH; 2) implement a dedicated GUI- based software package for performing a full reconstruction of the cerebral cortex from MR images; 3) implement surface-based processing and analysis tools within our dedicated software package that will allow definition of regions of interest on the cortex, cortical unfolding, surface editing, and sulcal labeling; 4) perform two phases of testing of the software package followed by a general public release; and 5) implement enhanced scripting and client/server-based versions of the software that will allow customization of the overall processing methodology and offload computationally intensive algorithms to a networked server. These aims will be achieved by 1) porting existing in-house software into the Java programming language using the MIPAV application programming interface, 2) developing graphical user interfaces for visualization and validation, and 3) making refinements based on tester feedback. Source code to all developed software will be made publicly available.

描述（由申请人提供）：该提案的目标是开发高度自动化且用户友好的软件工具，用于在体积磁共振（MR）图像中查找并以数学方式表示大脑皮层。 这些软件工4）衰老和疾病形态变化的表征。 构成所开发软件工具基础的算法源于我们自己在皮质重建和分析方面的研究工作。 我们提出了五个具体目标：1）将核心体积处理算法合并到 MIPAV 中，MIPAV 是 NIH 开发的商业质量但免费提供的软件包； 2) 实施基于 GUI 的专用软件包，用于根据 MR 图像对大脑皮层进行完整重建； 3) 在我们的专用软件包中实施基于表面的处理和分析工具，这将允许定义皮质上的感兴趣区域、皮质展开、表面编辑和脑沟标记； 4) 对软件包进行两个阶段的测试，然后进行公开发布； 5) 实施增强的脚本和基于客户端/服务器的软件版本，这将允许定制整体处理方法并将计算密集型算法卸载到网络服务器。 这些目标将通过以下方式实现：1) 使用 MIPAV 应用程序编程接口将现有的内部软件移植到 Java 编程语言中，2) 开发用于可视化和验证的图形用户界面，以及 3) 根据测试人员的反馈进行改进。 所有开发的软件的源代码将公开。