CORE--PATHOGEN FREE ANIMAL

核心——无病原体动物

• 批准号: 6605457
• 负责人: Lauretta W. Gerrity
• 金额: $ 19.59万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-02 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6605457
• 关键词: Rodentias; animal care; animal colony; biomedical facility; biomedical resource; germ free condition; isolation /quarantine; veterinary medicine

Description: (Applicant's Description) UAB Cancer Center Members increasingly depend on important animal models of human malignancy for translational research. These include immunodeficient rodents, cancer-bearing rodents that may be immunocompromised by experimental therapies, and extremely valuable transgenic animals with a wide assortment of physiologic, immunologic or pathologic modifications. The Pathogen-Free Rodent Shared Facility provides a unique support mechanism which produces and maintains pathogen-free rodents of special strains and stocks for use in studies by members of the Cancer Center. Through a systematic program of controlled access to the facility, personnel training, health screening of incoming animals, and close monitoring of the health status of animal subpopulations, a shared facility for state-of-the-art pathogen-free rodent management is provided in the Cancer Center?s 5100 NSF animal facility. The specific aims are: To provide a user-friendly, highly effective program for the provision of rodent animal models free of all indigenous pathogen infections for the support of translational research; To assist users of the Pathogen-Free Rodent Shared Facility in meeting their individual, often specialized, animal needs; To provide rigorous health screening of incoming animals, with quarantine in flexible film isolators at other campus locations until approved for entry into the shared facility; To closely monitor the health status of facility subpopulations, and to expeditiously remove, eliminate, or otherwise minimize the risks from animal stocks found to have significant pathogens, always in close consultation with investigators; and To closely supervise daily activities of the well qualified full-time Cancer Center animal husbandry staff selected for the facility in order to assure the consistent, high standard of animal care commensurate with the facility?s goals.

描述：（申请人的描述）UAB癌症中心成员越来越多 取决于人类恶性的重要动物模型用于翻译 研究。这些包括免疫缺陷啮齿动物，耐癌的啮齿动物 可以通过实验疗法进行免疫功能，并且非常有价值 具有各种生理，免疫学或各种各样的转基因动物 病理修饰。无病原体的啮齿动物共享设施提供了 独特的支持机制，产生和维持无病原体的啮齿动物 癌症中心成员在研究中使用的特殊菌株和库存。 通过系统的系统访问该设施的系统计划，人员 培训，对传入动物的健康筛查以及对 动物亚群的健康状况，这是最先进的共享设施 癌症中心5100 NSF提供无病原体的啮齿动物管理 动物设施。 具体目的是：提供一个用户友好，高效的程序 为了提供啮齿动物模型，没有所有土著病原体 支持转化研究的感染；协助用户 无病原体的啮齿动物共享设施，通常 专门的动物需求；提供严格的健康筛查 动物，在其他校园位置的灵活膜隔离器中有隔离 直到批准进入共享设施为止；密切监视 设施亚群的健康状况，并迅速删除， 消除或以其他方式最大程度地减少发现的动物股的风险 重要的病原体，总是与研究人员密切相关；然后 密切监督合格的全日制癌症的日常活动 中心畜牧人员被选为该设施，以确保 一致，高标准的动物护理与设施相称 目标。