NEURONAL AND CHEMICAL CONTROL OF BREATHING AN AIRWAYS FU

呼吸气道 FU 的神经元和化学控制

• 批准号: 6661846
• 负责人: MUSA A HAXHIU
• 金额: $ 10.31万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6661846
• 关键词: cooperative study; minority institution research support; neurochemistry; neuroregulation; pulmonary respiration

An adequate gas exchange and a sufficient supply of 02 to tissues depends on the patency of the airways which are regulated by central and peripheral nervous systems. The Howard University response to this RFA is based on the need for fundamental research in regard to central and peripheral nervous control of breathing and airway functions; including olfaction. Disturbances in neuronal regulatory mechanisms, as a consequences of alterations in sensory and/or motor innervations at different levels of organization, may cause serious health problems. To address some of these issues, we propose four interrelated projects. Project 1 will define central determinants of breathing and airway instability during behavioral changes by examining how CNS sites that regulate rapid eye movements (REM) and quiet (non-REM sleep might exert a differential control on respiratory related skeletal and airway smooth muscles. project 2 will study the neurochemical profile of the central chemoreceptor neurons, their receptor types, as well as their neuronal projections to respiratory and airway related motoneurons. Project 3 will investigate gene regulation involved in plasticity of the olfactory system as well as signaling during the acute phase response to physical, chemical and biological stressors. Project 4 will investigate the role of sensory innervation of the airway and gene regulatory mechanisms triggered by environmental agents, which operate in a feed forward manner enhancing airway inflammation and bronchoconstriction, and alterations in the signaling system linked to airway hyper-reactivity, airway narrowing and refractoriness to airway dilating influences. New investigative approaches will be used in these studies to answer questions which will enhance our understanding of the fundamental mechanisms underlying regulation of respiratory and airway functions. Furthermore, assembling a team of multi-disciplinary scientists from outside of the Howard University research community will enable us to generate new information that will advance knowledge, and ask relevant questions regarding future studies. This proposal is an expression of the commitments made by the College of Medicine, investing in infrastructure and guaranteeing long-term support, to bring talented researchers to work together. The university is committed to provide appropriate release time for the participants in this program to perform the research described herein.

足够的气体交换和足够的02向组织供应取决于气道的通畅性，而气道的通畅性受中央和周围神经系统调节。霍华德大学对这种RFA的反应是基于对呼吸和气道功能的中央和周围神经控制的基础研究的需求；包括嗅觉。神经元调节机制的扰动是导致不同组织水平的感觉和/或运动神经改变的后果，可能会导致严重的健康问题。为了解决其中一些问题，我们提出了四个相互关联的项目。项目1将通过检查调节快速眼动（REM）和安静的CNS位点如何在行为改变过程中定义呼吸和气道不稳定的核心决定因素（非REM睡眠可能对呼吸相关的骨骼和气道平滑肌产生差异性控制。项目2将研究中央化学神经元的神经化学术，以及他们的中央化学神经元的神经化学措施，以及他们的受体神经元的神经化学特征运动神经元将调查涉及嗅觉系统可塑性的基因调节，以及对物理，化学和生物压力源的急性响应。过度反应性，气道变窄和对气道膨胀影响的耐火性。这些研究将使用新的调查方法来回答问题，以增强我们对呼吸道和气道功能调节基本机制的理解。此外，组建来自霍华德大学研究社区外的多学科科学家团队将使我们能够生成新的信息，以提高知识，并就未来的研究提出相关问题。该提议表达了医学院所做的承诺，投资基础设施并保证长期支持，以使才华横溢的研究人员共同努力。该大学致力于为该计划的参与者提供适当的发布时间，以执行此处描述的研究。