Conference On Aminoacyl tRNA Synthetases

氨酰 tRNA 合成酶会议

• 批准号: 6365865
• 负责人: CHRISTOPHER S FRANCKLYN
• 金额: $ 0.2万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6365865
• 关键词: aminoacid tRNA ligase; biochemical evolution; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant) Aminoacyl-tRNA synthetases are key enzymes in protein synthesis and act as interpreters of the genetic code by relating amino acids to specific tri-nucleotides through aminoacylation of their cognate tRNAs. As such, their structure/function relationships provide important insights into early systems of the decoding machinery. This application describes a proposed workshop, entitled "Aminoacyl-tRNA Synthetases in Biology, Medicine, and Evolution," to be held at the Asilomar Conference, California, from September 23-28, 2001. Owing to the rapid pace of progress and interdisciplinary nature of the synthetase field, organization of this workshop is necessary. The format of the meeting will follow a Gordon Research Conference schedule, with a total of nine formal scientific sessions held in the mornings and evenings. Poster sessions and informal scientific discussions will take place in the afternoons. In each session, major talks of approximately 30 minutes duration will be given by senior investigators, and two to three additional short talks will also be presented by speakers selected on the basis of submitted abstracts. The nine sessions will focus on core issues of tRNA synthetase structure and function, as well as on additional topics of emerging interests. These include the mechanisms of specificity and editing, recognition of tRNA and tRNA-like molecules, alternative functions of synthetases, and artificial aminoacylation systems. This Asilomar meeting represents a unique opportunity to bring together both senior investigators in the field and younger scientists who are still establishing their careers. Participants will be chosen from a highly interactive group of scientists from a variety of disciplines, including representatives from the United States, Europe, and Japan. This is the fourth such meeting to be held in the last decade, with previous meetings held in Autrans, France (1990), Taos, New Mexico (1997), Mittelwihr, France (1998).

描述（由申请人提供） 氨酰基-tRNA 合成酶是关键酶 参与蛋白质合成并通过关联充当遗传密码的解释者 通过同源氨基酸的氨酰化将氨基酸转化为特定的三核苷酸 tRNA。因此，它们的结构/功能关系提供了重要的 深入了解解码机器的早期系统。这个应用程序 描述了一个拟议的研讨会，题为“生物学中的氨基酰基-tRNA 合成酶， 医学与进化”，将在加利福尼亚州阿西洛玛会议上举行， 2001 年 9 月 23 日至 28 日。由于进展迅速， 合成酶领域的跨学科性质，本次研讨会的组织 是必要的。会议的形式将遵循戈登研究 会议日程，共举行九场正式科学会议 早上和晚上。海报展示会和非正式的科学讨论 将在下午举行。每场会议的主要议题 高级调查员将提供大约 30 分钟的持续时间，并且 选定的演讲者还将进行两到三场额外的简短演讲 根据提交的摘要。九场会议将重点讨论核心 tRNA 合成酶的结构和功能问题，以及其他问题 新兴兴趣的话题。这些包括特异性和机制 编辑、tRNA 和 tRNA 样分子的识别、替代功能 合成酶和人工氨酰化系统。这次阿西洛玛会议 代表了一个将两位高级研究人员聚集在一起的独特机会 该领域和仍在建立自己职业生涯的年轻科学家。 参与者将从高度互动的科学家小组中选出 各个学科的代表，包括来自美国的代表， 欧洲、日本。这是去年召开的第四次此类会议 十年，之前的会议在法国奥特朗（1990 年）、新墨西哥州陶斯举行 (1997)，米特尔维，法国(1998)。