CRYSTAL STRUCTURE OF FIV DEOXYUTPASE (DU)

五脱氧酶 (DU) 的晶体结构

• 批准号: 6586636
• 负责人: C D STOUT
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586636
• 关键词: AIDS; bioimaging /biomedical imaging; biomaterials; biomedical resource; immunology; infection; inflammation; lymphatic system; nucleic acids; radiography; structural biology; virus

DU is an essential enzyme of nucleotide metabolism. The structure of the E. coli enzyme has been solved, but is partly disordered and the active site is not visualized. The crystal structure of FIV DU will permit design of drugs targeted at the enzyme active site, which may be effective anti-cancer agents.

DU是核苷酸代谢的必需酶。 结构 大肠杆菌酶的问题已得到解决，但部分是无序的， 活性位点不可见。 FIV DU的晶体结构 将允许设计针对酶活性位点的药物，这 可能是有效的抗癌剂。