STRUCTURE BASED DRUG DESIGN W/ HIV INTEGRASE

基于 HIV 整合酶结构的药物设计

• 批准号: 6586748
• 负责人: JASON R GREENWALD
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586748
• 关键词: AIDS; bioimaging /biomedical imaging; biomaterials; biomedical resource; enzymes; immunology; infection; inflammation; lymphatic system; proteins; radiography; structural biology; virus

We wish to collect data to determine the X-ray structure of the complex of the HNF-1a dimerization domain and DcoH. This would allow us to define interactions that mediate recognition and characterize any conformational changes that may help stimulate gene expression.

我们希望收集数据来确定 X 射线结构 HNF-1a 二聚化结构域和 DcoH 的复合物。 这将允许 我们定义介导识别和表征的交互 任何可能有助于刺激基因表达的构象变化。