XRAY CRYSTALLOGRAPHIC STUDIES OF MURZ ENZYME

Murz 酶的 X 射线晶体学研究

• 批准号: 6586540
• 负责人: CHRISTIN A FREDERICK
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586540
• 关键词: bioimaging /biomedical imaging; biomaterials; biomedical resource; infection; proteins; radiography; structural biology

The involvement of MurZ in bacterial cell wall biosynthesis makes the enzyme a potential target for the development of new antibacterial agents and indeed, MurZ is the site of action of the antibiotic fosfomycin. The three dimensional structure of MurZ will be very helpful for understanding the mechanism of this enzyme and designing new antibacterial drugs.

MurZ 参与细菌细胞壁生物合成使得 该酶是开发新型抗菌剂的潜在目标 事实上，MurZ 是抗生素的作用位点 磷霉素。 MurZ的三维结构将非常 有助于理解该酶的机制和设计 新型抗菌药物。