END-STAGE LIVER DISEASE/PREVALENCE & TREATMENT VARIATION

终末期肝病/患病率

• 批准号: 6643525
• 负责人: CINDY L BRYCE
• 金额: $ 12.47万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-15 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6643525
• 关键词: behavioral /social science research tag; clinical research; epidemiology; gender difference; human data; liver failure; liver transplantation; racial /ethnic difference; socioeconomics

DESCRIPTION (adapted from the application) The primary purpose of this proposal is to provide the applicant with means and structure for achieving two goals. The immediate goal is to evaluate the effect of gender, race and income on access to liver transplant services. The long-term goal is to gain independence as a health services researcher by developing methodological expertise in decision sciences and multivariate statistical modeling and research expertise in organ transplantation and health policy evaluation. The applicant will obtain further instruction in computer simulation, geographic information systems, and advanced statistical analysis; in addition, she will receive clinical education to better understand the liver transplantation process and overall delivery of patient care. This training will be provided through formal coursework, directed readings, seminars and conferences, a clinical preceptorship, and research. Most activities will take place at the University of Pittsburgh's School of Medicine, Graduate School of Public Health, and Center for Research on Health Care. The applicant's research project evaluates the role of gender, race, and income in determining access to liver transplantation and explaining variation in liver transplant rates. To date, most studies on access to transplantation have focused on renal transplant services; few researchers have studied hepatic transplantation because of serious data limitations. Whereas the federal government maintains a comprehensive database of persons with renal disease from the time they receive dialysis, there is no centralized, population-based registry for persons with end-stage liver disease (ESLD). Most information on ESLD patients is collected on liver transplant candidates by the United Network for Organ Sharing. The hypothesis of this project is that demographic and economic factors significantly affect early access to transplant services, namely referral rates to transplant centers and listing rates by transplant centers. To address this issue, better information is needed. Therefore, the project will satisfy two aims: (1) develop and validate a population-based methodology for identifying and tracking a cohort of "transplant potential" patients with ESLD; and (2) estimate the effect of gender, race and income on movement through the transplantation process. This project will collect new information on patients with ESLD and combine it with existing data resources made available through The Optimal Timing of Liver Transplantation Project (AHCPR, R01 HS09694-02).

描述（根据应用程序改编） 该提案的主要目的是为申请人提供手段和 实现两个目标的结构。直接目标是评估效果 性别，种族和收入获得肝移植服务的收入。这 长期目标是作为医疗服务研究人员获得独立性 在决策科学和多元方面发展方法论专业知识 器官移植和健康方面的统计建模和研究专业知识 政策评估。申请人将在计算机上获得进一步的指导 模拟，地理信息系统和高级统计分析； 此外，她将接受临床教育，以更好地了解肝脏 移植过程和患者护理的总体分娩。这个培训 将通过正式课程，定向阅读，研讨会和 会议，临床主持和研究。大多数活动将进行 位于匹兹堡大学医学院，研究生院 公共卫生和医疗保健研究中心。 申请人的研究项目评估性别，种族和收入的作用 在确定进入肝移植并解释差异时 肝移植率。迄今为止，大多数有关移植的研究 专注于肾脏移植服务；很少有研究人员研究肝 由于严重的数据限制而移植。而联邦 政府维持一个肾脏疾病患者的全面数据库 从他们接受透析的时候，就没有集中式的，基于人口的集中式 终末期肝病（ESLD）的人注册表。大多数信息 ESLD患者是由联合网络收集在肝移植候选者上的 用于器官共享。该项目的假设是人群和 经济因素显着影响早期获得移植服务的机会， 即转介率转介到移植中心，并通过移植率上市率 中心。为了解决此问题，需要更好的信息。因此， 项目将满足两个目标：（1）开发和验证基于人群的 识别和跟踪“移植潜力”队列的方法 ESLD患者； （2）估计性别，种族和收入对 通过移植过程运动。这个项目将收集新的 有关ESLD患者的信息，并将其与现有数据资源相结合 通过肝移植项目的最佳时机提供 （AHCPR，R01 HS09694-02）。