CENTER FOR INVIRONMENATL GENOMICS

环境基因组学中心

• 批准号: 6524823
• 负责人: David A Schwartz
• 金额: $ 171.35万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6524823
• 关键词: environmental health; gene expression

DESCRIPTION (provided by applicant) Despite the tremendous inter-individual variability in the respond to environmental toxins, the investigators simply do not understand why certain people develop disease when challenged with environmental agents and others remain healthy. Yet, there is emerging consensus that many of the complex (and prevalent) diseases that humans develop occur as a result of multiple biologically unique gene-gene and gene-environment interactions. The recent advances in human and molecular genetics has provided an unparalleled opportunity to understand how genes and genetic changes interact with environmental stimuli to either preserve health or cause disease. The theme of this Center is to use gene expression profiling to understand the effect of environmental stresses on human health. This will be accomplished by establishing an interdisciplinary Center that supports the use of complementary biologic systems (humans, mice, zebrafish and worms) to investigate the role of genetic susceptibility in the pathogenic response to specific types of environmental stress (bacteria, malnutrition, and metals). This approach will enable the investigators to develop and investigate environmental models of human disease that represent biologically unique gene-environment- pathophysiological phenotypes. Microarray analyses will be used to comprehensively evaluate the biological response to environmental stress and to identify pathogenic mechanisms that are relevant to innate immunity, neural tube defects, and transition metal toxicity. The end result is a broad based yet highly integrated program that has the potential to make a number of novel, related observations. The overall hypothesis unifying this research program is that gene expression profiling will identify genes and pathogenic processes that are critical to human environmental health and disease. In aggregates the coupled scientific findings from the proposed Program will substantially enhance our understanding of environmental toxicology and genomics.

描述（由申请人提供） 尽管响应中有很大的个体间差异 环境毒素，调查人员根本不明白为什么 人们在面对环境因素和其他人的挑战时发展疾病 保持健康。然而，有许多复杂的共识 （且普遍）人类出现的疾病是由于多重的 生物学独特的基因基因和基因环境相互作用。最近 人类和分子遗传学的进步提供了无与伦比的 了解基因和遗传变化如何与 环境刺激要么保留健康或引起疾病。主题 这个中心的是使用基因表达分析来了解 环境压力人类健康。这将通过 建立一个支持使用的跨学科中心 互补的生物系统（人类，小鼠，斑马鱼和蠕虫） 研究遗传易感性在致病反应中的作用 特定类型的环境应力（细菌，营养不良和金属）。 这种方法将使研究人员能够开发和调查 人类疾病的环境模型，代表生物学上独特的基因环境 - 病理生理表型。将使用微阵列分析 全面评估对环境压力的生物学反应 并确定与先天免疫相关的致病机制， 神经管缺陷和过渡金属毒性。最终结果是广泛的 基于高度集成的程序，有可能制作许多 新颖的，相关的观察。整体假设统一了这项研究 程序是基因表达分析将识别基因和致病性 对人类环境健康和疾病至关重要的过程。在 拟议程序的耦合科学发现将 大大增强了我们对环境毒理学和 基因组学。