CORE--MEASUREMENT SERVICES

核心——测量服务

• 批准号: 6651318
• 负责人: RICHARD N PIERSON
• 金额: $ 14.86万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6651318
• 关键词: activation analysis; biomedical equipment resource; biomedical facility; body composition; clinical research; densitometry; functional ability; human subject; magnetic resonance imaging; morphometry; photon absorptiometry; plethysmography; quality of life; technology /technique development

Core A of the proposed Program Project Grant (PPG) III provides four types of services to the projects: body composition, functional, and quality of life measurements; guidance for appropriate method selection; advice on interpretation of results; and collaborative development of new body composition methods and models. Body composition methods and measurements available to investigators in the projects include: in vivo neutron activation analysis (IVNA) for whole-body N, C, and O; whole-body and regional magnetic resonance imaging (MRI)/spectroscopy for all major tissue-system level body composition components and tissue lipids in humans and animals; whole- body and regional 40K for total body and forearm potassium; dual energy x-ray absorptiometry for whole-body and regional soft tissue and bone mineral; body volume by hydrodensitometry and air plethysmography; deuterium and bromide dilution volumes for total body and extracellular water; bioimpedance analysis (BIA) for resistance and reactance of whole-body regions, and isolated tissues; and anthropometry. Core Unit A has grown and developed substantially over this cycle of the PPG. New space was provided by the Hospital for expanded and new facilities including an IVNA, MRI Analysis, BIA, and Regional 40K Laboratories. The new Core C grew up of the growing and productive data analysis and modeling efforts of the present members of Core A. Core C grew out of the growing and productive data analysis and modeling efforts of the present members of Core A. Close collaborations and interactions with Core B members are leading to new and innovative method development and to cross-validation of state-of-the art methods (e.g., IVNA) transferred from their Department of Energy development site at Core C Brookhaven National Laboratory to Core A at St. Luke's- Roosevelt Hospital. An important extension of Core A projects and collaborations is the association with Department of Biomedical Engineering and collaborative projects at University's high-field strength Hatch MRI facility. The Core's productivity is evident not only in the large number of project-related measurements, but in the many peer-reviewed body composition, functional, and quality of life papers authored by Core members and their collaborators. The large number and diversity of proposed measurements reflect the Core's central role in this overall proposed program.

拟议计划项目赠款（PPG）III的核心A为项目提供了四种类型的服务：身体组成，功能和生活质量测量；选择适当的方法指南；有关结果解释的建议；以及新的身体组成方法和模型的协作开发。项目中可用于研究人员的身体组成方法和测量包括：全身N，C和O的体内中子激活分析（IVNA）；所有主要组织系统水平的身体组成成分和人类和动物的组织脂质的全身和区域磁共振成像（MRI）/光谱；全身和区域40K，用于全身和前臂钾；双能X射线吸收法，用于全身和区域软组织和骨矿物质；体积通过水透射测定法和空气散布图；氘和溴化物稀释量，用于总体和细胞外水；生物阻抗分析（BIA），用于全身区域的耐药性和抗性；和人体测量法。核心单元A在PPG的这一周期中已经成长和发展。医院提供了新的空间，用于扩展和新设施，包括IVNA，MRI分析，BIA和区域40K实验室。新的核心c在核心A.核心目前成员的日益增长和生产性数据分析和建模工作中成长，从不断增长的生产性数据分析和建模核心A的成员A.的紧密合作和与核心B成员的互动的工作中，导致了新的和创新的方法开发，并导致了核心方法（例如，兄弟的核心范围）的核心工具（例如，iiv nec. iv necter of thern of themna cornection of themna cornection of thern of the the core core core core core core core core core core core core cor a in v。在圣卢克斯 - 罗斯福医院。核心A项目和合作的一个重要扩展是与大学高场实力HATH MRI设施的生物医学工程和协作项目的关联。核心的生产率不仅在大量与项目相关的测量中很明显，而且在许多经过同行评审的身体组成，功能和生活质量论文中，由核心成员及其合作者撰写。拟议测量的大量和多样性反映了核心在该总体计划中的核心作用。