MEDICAL APPLICATIONS--HIGH PRECISION IN BODY COMPOSITION

医疗应用——高精度身体成分

• 批准号: 2867577
• 负责人: RICHARD N PIERSON
• 金额: $ 3.48万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2867577
• 关键词: activation analysis; body composition; muscle metabolism

In vivo body composition measurements are vital to research in growth and development, the aging process, the malnutritions, and pathologies such as osteoporosis and the acquired immunodeficiency syndrome. In vivo neutron activation analysis (IVNA) has become the most basic, the most precise, and the most accurate reference standard for quantifying human body composition, though rarely available. Its effectiveness has been demonstrated in studies on osteoporosis, cancer, effects of growth hormone, thalassemia, nutritional deficiencies, and alcoholism. However, its application is limited in the range of subject height and weight for which calibrations are available. This proposal defines 1) the optimal use of IVNA to study body composition in four clinical projects which require precise and accurate measurements in human subjects; 2) the use of Monte Carlo simulations and phantom studies to improve the precision and the accuracy of the IVNA studies and to extend them to leaner and fatter subjects; 3) the application of new compartmental models to analyze the data; and 4) the development of the BNL IVNA facility to a reference laboratory for IVNA techniques and applications; and 5) the establishment of translation tables to calibrate proposed non-invasive methods which may serve as surrogates for IVNA. This project will assemble in one administrative structure the mechanism for applying the state-of-the-art techniques for measuring elemental and compartmental body composition methods to clinical projects: IVNA to measure total body C, N, Na, P, Cl, K, and Ca, which provide also total body fat and lean mass; dual photon absorptiometry to measure bone mineral content and body lean and fat mass; isotopic dilution; total body electrical conductivity; and bioelectric impedance analysis. The basic science for calibration, validation, and analytic modeling will be centered in the Core laboratory at BNL, with participation by the Columbia University group. The clinical projects will be centered int eh laboratories of the four principal investigators of the projects in New York City, Nassau County, and Boston, with the administrative core centered at the St. Luke's site in New York. Results from these research projects together will provide a wide range of normal reference data, and a significant reduction in cost for the planned studies in each project. This proposal will strengthen the field of body composition research by establishing national standard for most body composition measurement techniques.

体内身体组成测量对于研究至关重要 增长与发展，衰老过程，营养不良和 诸如骨质疏松症和获得的病理 免疫缺陷综合征。 体内中子激活分析 （IVNA）已成为最基本，最精确和最重要的 量化人体的准确参考标准 构图，尽管很少可用。 它的有效性已经 在有关骨质疏松症，癌症的研究中证明了 生长激素，thalassya，营养缺乏症和 酗酒。 但是，其应用在 主题的高度和重量可用。 该建议定义了1）IVNA研究身体的最佳用途 在四个需要精确的临床项目中的组成 人类受试者的准确测量； 2）使用蒙特 卡洛模拟和幻影研究以提高精度 以及IVNA研究的准确性，并将其扩展到更精益 和胖乎乎的主题； 3）新隔室的应用 分析数据的模型； 4）BNL的发展 IVNA设施是IVNA技术参考实验室的 申请； 5）建立翻译表 校准提出的非侵入性方法，可以用作 替代IVNA。 该项目将在一个管理结构中组装 应用最新技术的机制 测量元素和隔室的身体组成方法 临床项目：IVNA测量总体C，N，NA，P，CL， K和Ca，还提供总体脂肪和瘦质量；双重的 测量骨矿物质含量和身体的光子吸收法 瘦和脂肪；同位素稀释；总体电气 电导率；和生物电阻抗分析。 基本 校准，验证和分析建模的科学将 以BNL的核心实验室为中心 哥伦比亚大学小组。 临床项目将是 四个主要研究人员的中心实验室 在纽约市，拿骚县和波士顿的项目中 行政核心集中在新的圣卢克网站 约克。 这些研究项目的结果将提供广泛的 正常参考数据范围，显着降低 每个项目计划研究的成本。 该提议将 通过建立 大多数身体组成测量的国家标准 技术。