Behavioral correlates of fMRI response in cocaine users

可卡因使用者功能磁共振成像反应的行为相关性

• 批准号: 6650822
• 负责人: Rita Z Goldstein
• 金额: $ 12.53万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6650822
• 关键词: behavior prediction; behavioral /social science research tag; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain mapping; clinical research; cocaine; drug abuse; functional magnetic resonance imaging; human subject; psychopharmacology; relapse /recurrence; substance abuse related behavior

DESCRIPTION (provided by applicant): This is an application written in response to RFA PA-00-004. It describes a systematic 5-year training plan to launch an independent research career in the cognitive and emotional neuroscience of human cocaine addiction through the use of functional magnetic resonance imaging (fMRI), a powerful technique that allows simultaneous, non-invasive measurement of brain activation and cognitive performance. This plan will allow the candidate, a Clinical Psychologist with background in Neuropsychology, to initiate technologically sophisticated research of relevance to treating cocaine addiction. This goal will be achieved through a rigorous training plan, integrating didactic and research components tailored to the candidate's goals and experience. Brookhaven National Laboratory (BNL) provides an ideal training environment: 1) BNL is home to state-of-the-art functional neuroirnaging technologies; and 2) The mentors of this project are world renowned for the application of these cutting-edge technologies to study mechanisms of drug addiction. Under their supervision the candidate will conduct fMRI (4T) activation projects designed to evaluate whether adaptations to the frontolimbic circuit underlie deficits in salience attribution and response inhibition in cocaine addicted subjects, and whether these neuroadaptations and cognitive-behavioral impairments can be used to predict and monitor relapse. In Project 1, subjects receive different levels of Monetary Incentive for correct performance on a go/no-go task. In Project 2, subjects perform a Drug Stroop task, naming the color of cocaine-related words, neutral words, or non-words. Project 3 is a longitudinal study, where subjects undergo Projects 1 & 2 at baseline (2-4 weeks after detoxification) and 6 months follow-up. In all projects, we measure the blood oxygenation level dependent (BOLD) responses of the frontolimbic circuit including the orbitofrontal cortex (OFC) and anterior cingulate gyrus (ACG). We hypothesize: 1) Task specificity: the Monetary Incentive task will primarily activate the OFC while the Drug Stroop task will primarily activate the ACG; 2) Group specificity: the activation of the frontolimbic circuit by the two cognitive-behavioral tasks will differ as a function of drug addiction; and 3) Relapse prediction and monitoring: increased frontolimbic activation and impaired cognitive-behavioral performance at baseline will characterize the cocaine addicted subjects and predict relapse at 6-months follow up. For the subjects who will relapse, abnormalities in these brain-behavior measures will remain the same or get worse during the follow-up period while for the subjects who will remain abstinent, normalization of these measures will be documented.

描述（由申请人提供）：这是针对RFA PA-00-004编写的申请。 它描述了一项系统的5年培训计划，该计划通过使用功能磁共振成像（FMRI）来启动人类可卡因成瘾的认知和情感神经科学的独立研究职业，这是一种强大的技术，允许同时，无创的脑激活和认知性能测量。 该计划将使具有神经心理学背景的临床心理学家候选人能够启动与可卡因成瘾有关的技术复杂研究。 这一目标将通过严格的培训计划来实现，集成了针对候选人的目标和经验量身定制的教学和研究组件。 Brookhaven国家实验室（BNL）提供了理想的培训环境：1）BNL是最先进的功能性神经启动技术的所在地； 2）该项目的指导者以这些尖端技术在研究药物成瘾机制中的应用而闻名。 在他们的监督下，候选人将进行fMRI（4T）激活项目，旨在评估可卡因成瘾受试者显着归因和抑制作用的适应性，以及这些神经适应性和认知行为障碍是否可以用于预测和监测和监测和监测和监测。 在项目1中，受试者会在GO/No-Go任务上获得不同级别的货币激励措施。 在项目2中，受试者执行毒品stroop任务，命名与可卡因相关的单词，中性单词或非单词的颜色。 项目3是一项纵向研究，该研究受试者在基线时（排毒后2-4周）和6个月的随访。 在所有项目中，我们测量了额骨电路的血液氧合水平依赖性（粗体）响应，包括眶额皮层（OFC）和前扣带回回（ACG）。 我们假设：1）任务特异性：货币激励任务将主要激活OFC，而药物stroop任务将主要激活ACG； 2）群体特异性：两个认知行为任务通过两种认知行为的激活将随着药物成瘾的函数而有所不同； 3）复发预测和监测：基线时的额骨激活增加和认知行为表现受损，将表征可卡因上瘾的受试者，并预测6个月后续时间的复发。 对于将复发的受试者，在随访期间，这些大脑行为措施中的异常情况将保持不变或变得更糟，而对于将保持戒烟的受试者，将记录这些措施的归一化。