TRENDS IN TRANS-FATTY ACID INTAKE BETWEEN 1980 AND 1997

1980 年至 1997 年反式脂肪酸摄入量趋势

• 批准号: 6390678
• 负责人: LISA HARNACK
• 金额: $ 7.11万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6390678
• 关键词: cardiovascular disorder epidemiology; clinical research; dietary lipid; disease /disorder proneness /risk; health surveys; human data; nutrition related tag; unsaturated fatty acids

DESCRIPTION (Adapted from the applicant's abstract) In recent years concern has arisen about the potential health hazards of trans-fatty acids in the American diet. Dietary intake of trans-fatty acids has been linked to unhealthy shifts in serum lipid profiles and to coronary heart disease (CHD) in a number of studies. Although several studies have estimated intakes of trans-fatty acids in U.S. populations, presently data is lacking regarding trends in intake of trans-fatty acids in the population. Furthermore, it is unclear how trends in intake of trans-fatty acids may be related to changes in other dietary and non-dietary CHD risk factors and CHD mortality. This proposal aims to utilize newly available nutrient data to recalculate dietary data collected as part of the Minnesota Heart Survey (MHS) to examine trends in intake of trans-fatty acids. The MHS is an ongoing observational epidemiologic study of trends in risk factors and cardiovascular morbidity and mortality among independent cross-sectional probability samples of the Minneapolis-St. Paul, Minnesota, metropolitan area. Surveys were conducted in 1980-1982, 1985-1987, 1990-1992 and 1995-1997. Diet was among the CVD risk factors measured as part of each survey. In this research, 24-hour dietary recalls collected from MHS participants will be recalculated using an updated food and nutrient database that includes trans-fatty acid values (16:1, 18:1, 18:2, and total). Intake estimates resulting from recalculation will be analyzed to examine temporal trends in trans-fatty acid intake between 1980 and 1997, and to examine the relationship of temporal trends in trans-fatty acid intake to temporal changes in other dietary and non-dietary CHD risk factors and changes in CHD mortality. The MHS data provide a unique opportunity to examine a dietary constituent only recently recognized as a potential risk factor for CHD.

描述 （改编自申请人的摘要）近年来引起了人们的关注 关于美国饮食中反式脂肪酸的潜在健康危害。 饮食中反式脂肪酸的摄入与不健康的转变有关 血清脂质谱和冠心病（CHD）在许多 研究。 尽管一些研究估计了反式脂肪酸的摄入量 在美国人口中，目前缺乏关于摄入量趋势的数据 人群中的反式脂肪酸。 此外，尚不清楚趋势如何 反式脂肪酸的摄入可能与其他饮食习惯的变化有关 非饮食性 CHD 危险因素和 CHD 死亡率。 该提案旨在利用新获得的营养数据来重新计算 作为明尼苏达州心脏调查 (MHS) 的一部分收集的饮食数据用于检查 反式脂肪酸摄入量的趋势。 MHS 是一项持续观察 危险因素和心血管发病率趋势的流行病学研究 独立横截面概率样本中的死亡率 明尼阿波利斯-圣。明尼苏达州保罗都会区。 调查进行于 1980-1982 年、1985-1987 年、1990-1992 年和 1995-1997 年。 饮食是CVD风险之一 作为每次调查的一部分进行衡量的因素。 在这项研究中，24小时饮食 从 MHS 参与者收集的召回信息将使用更新后的数据重新计算 食品和营养数据库，包括反式脂肪酸值（16:1、18:1、 18:2，总计）。 重新计算得出的摄入量估计值将是 分析以检查 1980 年间反式脂肪酸摄入量的时间趋势 和 1997 年，并研究反式脂肪的时间趋势的关系 酸摄入量对其他饮食和非饮食冠心病风险的暂时变化 CHD 死亡率的因素和变化。 MHS 数据提供了检查膳食成分的独特机会 最近才被认为是冠心病的潜在危险因素。

项目成果

Trends in the trans-fatty acid composition of the diet in a metropolitan area: the Minnesota Heart Survey.

大都市区饮食中反式脂肪酸组成的趋势：明尼苏达州心脏调查。

• 发表时间: 2003-09
• 作者: Harnack, Lisa;Lee, Seungmin;Schakel, Sally F;Duval, Susan;Luepker, Russell V;Arnett, Donna K
• 通讯作者: Arnett, Donna K

Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor.

Rab1 GTPase 和二聚化在细胞表面表达血管紧张素 II 2 型受体。

• 发表时间: 2009-07
• 作者: Zhang, Xiaoping;Wang, Guansong;Dupre, Denis J;Feng, Yumei;Robitaille, Melanie;Lazartigues, Eric;Feng, Ying;Hebert, Terence E;Wu, Guangyu
• 通讯作者: Wu, Guangyu