FUNCTIONAL MRI FOR EARLY DIAGNOSIS OF ALZHEIMER DISEASE

用于阿尔茨海默病早期诊断的功能 MRI

• 批准号: 6346403
• 负责人: GARY William SMALL
• 金额: $ 0.77万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6346403
• 关键词: bioimaging /biomedical imaging; biomedical resource; child (0-11); computers; female; magnetic resonance imaging; male; mental disorders; model design /development; nervous system; nuclear magnetic resonance spectroscopy; statistics /biometry

The capacity to respond secretion of cortisol is one of the central features of this response. Although cortisol release is critical to stress adaptation, sustained release in the face of ongoing stress may cause adverse effects. The hippocampus, a component of the brain limbic system. plays an important role in terminating the stress response. In addition, the hippocampus is involved in the regulation of emotion as well as in learning and memory. While studies of juvenile depressed patients have consistently reported increased stressful experiences. elevated cortisol secretion and memory deficits. to our knowledge, there are no studies which have examined the associations among chronic stress, cortisol secretion, and hippocampal and cognitive function. It is the goal of this study- to analyze the relationship between the size of the hippocampus. salivary and U urinary cortisol. and memory function in four groups of adolescents (namely, depressed adolescents with high-level 3 chronic s tress. depressed adolescents with low-level stress, normal adolescents with low-level stress and normal adolescents with high-level chronic stress). Specific Aims Using a controlled design, the study aims to examine the relationships among chronic life stress, changes in the limbichypothalamic-pituitary-adrenal (LHPA) system and neuropsychological function in adolescent depression. Specifically, measures of hippocampal volume, salivary and urinary cortisol, as well as memory function will be compared. We intend to test the following hypotheses: Depressed adolescents with high-level chronic stress will have: (1) decreased hippocampal volume (3) higher salivary cortisol (4) elevated urinary cortisol (5) non-verbal memory deficits compared to depressed adolescents with low-level stress and normal adolescents with low-level stress.

响应皮质醇的分泌能力是 此响应的主要特征。 虽然皮质醇释放是 对压力适应至关重要，面对 持续的压力可能会导致不利影响。 海马，a 大脑边缘系统的组成部分。 在 终止压力反应。 另外，海马是 参与情感以及学习和学习的调节 记忆。 少年抑郁症患者的研究有 一贯报告压力的增加。 高架 皮质醇分泌和记忆缺陷。 据我们所知，有 没有研究检查慢性应激之间的关联的研究， 皮质醇分泌以及海马和认知功能。 是 本研究的目标 - 分析规模之间的关系 海马。 唾液和U尿皮质醇。 和内存 在四组青少年中的功能（即沮丧的青少年 具有高级3慢性S Tress。 沮丧的青少年 低级应力，低水平应力和正常的正常青少年 具有高级慢性应激的青少年）。 具体目标 该研究使用受控设计，旨在检查关系 在慢性生活压力中，变化 Limbichypothalamic-Pituitary-肾上腺（LHPA）系统和 青少年抑郁症的神经心理学功能。 具体来说， 海马体积，唾液和尿皮质醇的度量 由于记忆函数将被比较。 我们打算测试以下 假设：具有高慢性压力的青少年抑郁症 有：（1）海马体积减少（3）唾液皮质醇较高 （4）比较尿皮质醇（5）非语言记忆缺陷 对于低水平压力和正常青少年的抑郁青少年 具有低水平的压力。