A Diffusion Tensor Imaging Study of HIV-Dementia

HIV-痴呆的弥散张量成像研究

• 批准号: 6616086
• 负责人: ANN B RAGIN
• 金额: $ 10.54万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6616086
• 关键词: AIDS dementia complex; biomarker; blood brain barrier; cerebrospinal fluid; clinical research; dementia; human subject; longitudinal human study; magnetic resonance imaging; neural degeneration; neuropsychology; patient oriented research; plasma; tumor necrosis factor alpha

DESCRIPTION (provided by applicant): This K23 application requests a period of career development to study advanced methods in Magnetic Resonance (MR) imaging and exploit them to study HIV-Dementia (HIV-D). Emerging MR methods provide microstructural information concerning white matter that cannot be obtained using other imaging techniques. Diffusion Tensor Imaging (DTI) is a non-invasive technique that may be useful in studying white matter integrity in normal, diseased or degenerating tissue in vivo. HIV-Dementia (HIV-D) is characterized by various pathologies involving white matter. This study represents an opportunity to evaluate information uniquely revealed by DTI in the context of other meaningful biological and clinical parameters. Subjects in this investigation will include well-characterized patients from a large, longitudinal cohort study_ef HIV-D. Extensive data is available from semi-annual evaluations over a number of years, including biological markers derived from plasma and CSF, as well as information concerning neurocognitive and psychiatric functioning. This study will determine whether microstructural measures of white matter integrity, derived using DTI, bear a relation to measures of advancing HIV infection (e.g. viral load and immune activation), severity of dementia and specific neuropsychiatric sequelae. In addition, the DTI findings will be evaluated in the context of biological markers of theoretical interest, including select measures of inflammation (e.g. TNF ) and endothelial integrity (e.g. MMP-9). These findings will contribute to an understanding of the pathogenesis of HIV-D and may provide insights concerning other CNS disorders. Experience gained during the proposed award will lay the foundation for further independent investigations of neurobiological factors in HIV-D.

描述（由申请人提供）：此K23申请要求一段职业发展，以研究磁共振成像（MR）成像中的先进方法，并利用它们来研究HIV抑制剂（HIV-D）。新兴的MR方法提供了有关使用其他成像技术无法获得的有关白质的微结构信息。扩散张量成像（DTI）是一种非侵入性技术，可用于研究体内正常，患病或退化组织中的白质完整性。 HIV止血（HIV-D）的特征是涉及白质的各种病理。这项研究代表了在其他有意义的生物学和临床参数的背景下，DTI唯一揭示的信息的机会。这项调查的受试者将包括来自大型纵向队列研究_EF HIV-D的良好表征的患者。多年来，半年度评估可从血浆和CSF衍生的生物学标记以及有关神经认知和精神病功能的信息获得广泛的数据。这项研究将确定使用DTI得出的白质完整性的微观结构测量是否与前进的HIV感染（例如，病毒载量和免疫激活），痴呆症的严重程度和特定的神经精神后遗症有关。此外，DTI发现将在理论兴趣的生物学标记的背景下进行评估，包括精选的炎症度量（例如TNF）和内皮完整性（例如MMP-9）。这些发现将有助于理解HIV-D的发病机理，并可能提供有关其他中枢神经系统疾病的见解。在拟议的奖励期间获得的经验将奠定基础，以进一步独立研究HIV-D中的神经生物学因素。