Effects of perinatal endocrine disrupters in children

围产期内分泌干扰物对儿童的影响

• 批准号: 6656295
• 负责人: PHILIPPE ADAM GRANDJEAN
• 金额: $ 29.28万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6656295
• 关键词: Scandinavian; age difference; behavior disorders; behavioral /social science research tag; blood tests; child (0-11); child psychology; clinical research; developmental neurobiology; endocrine disorder; endocrine gland /system; environmental exposure; environmental toxicology; epidemiology; exotoxins; gender difference; growth /development; halobiphenyl /halotriphenyl compound; hormone regulation /control mechanism; human subject; longitudinal human study; nervous system disorder; neuropsychological tests; neuropsychology; perinatal; statistics /biometry

DESCRIPTION: Prenatal exposures to endocrine disruptors, including several organochlorine pollutants, have been linked to developmental abnormalities and neurobehavioral deficits, but causal associations and dose-response relationships are unclear. A birth cohort of 182 children was formed in 1994 at the Faroe Islands, where increased exposures to these substances mainly originates from consumption of pilot whale blubber. This North Atlantic fishing community is unique and highly suitable for prospective population-based studies, because exposure levels vary more than 100-fold due to differences in dietary habits. Stored maternal serum from week 34 of pregnancy will now be used to characterize the endocrine disruption potential expressed as activation of the estrogen receptor and the Ah receptor. Postnatal exposure levels will be determined from analysis of serum collected from the children. Exposures to methylmercury and essential nutrient status will also be determined. Data on growth and development from annual examinations up to age 5.5 years are available and will now be supplemented by examinations at ages 7 and 9 years, when advanced testing will be applied to assess sexually dimorphic behaviors, domain-related neurobehavioral function, serum hormone concentrations, and developmental markers of early puberty development. Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally.

描述： 产前暴露于内分泌破坏者，包括几种有机氯 污染物与发育异常和神经行为有关 缺陷，但是因果关系和剂量反应关系尚不清楚。 1994年在法罗群岛成立了182名儿童的出生队列 对这些物质的暴露量增加主要来自于消费 飞行员鲸鱼泡沫。这个北大西洋捕鱼社区是独一无二的 适用于前瞻性基于人群的研究，因为暴露水平有所不同 由于饮食习惯的差异，超过100倍。储存的母血清 从怀孕的第34周开始，现在将用于表征内分泌 破坏势表示为雌激素受体的激活和 AH受体。产后暴露水平将从分析中确定 从孩子那里收集的血清。暴露于甲基汞和必不可少的 营养状况也将得到确定。关于增长和发展的数据 可提供5.5岁以下的年度考试，现在将是 通过7岁和9岁的考试补充，高级测试将 用于评估性二态行为，与域相关的行为 神经行为功能，血清激素浓度和发育 早期青春期开发的标志。现代统计方法将使用 为了确定这些结果变量是否与雌激素相关， 甲状腺或AH受体异常和特定污染物暴露 产前或产后。