Assessment of PFAS exposures and health effects in two Massachusetts communities with PFAS drinking water contamination

评估马萨诸塞州两个受 PFAS 饮用水污染的社区的 PFAS 暴露和健康影响

• 批准号: 10441118
• 负责人: PHILIPPE ADAM GRANDJEAN
• 金额: $ 125万
• 依托单位: SILENT SPRING INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10441118
• 关键词: Assessment; PFAS; exposures; health; effects

ABSTRACT Across the U.S., a growing number of drinking water supplies have been found to be contaminated with per- and polyfluoroalkyl substances (PFAS). We first found that at least six million Americans in 22 states receive drinking water from sources that exceeded EPA’s 2016 guideline for PFOS and PFOA, and over 100 million Americans are estimated to have PFAS in their tap water. Over 400 DoD sites have known or suspected releases of PFAS. Our team found that proximity to military fire training areas and airports strongly predicts drinking water contamination due to the use of PFAS-containing aqueous film-forming foam (AFFF) for liquid fuel fires. Health concerns related to PFOA and PFOS include cancer, liver toxicity, high cholesterol, and reproductive and developmental effects. Following our first report on immunotoxicity, a 2016 National Toxicology Program systematic review concluded that both PFOS and PFOA are presumed immune hazards to humans. While elevated total cholesterol has been associated with PFAS exposure, our preliminary evidence suggests associations with specific lipoprotein subfractions that predict risk of cardiovascular disease. Despite the growing number of communities with documented PFAS exposures, there have been few epidemiological studies in communities with PFAS-impacted drinking water. As part of ATSDR’s multi-site study of health effects associated with exposures to PFAS-contaminated drinking water, we propose a study of PFAS health effects in two communities in Eastern Massachusetts where public drinking water supplies have been contaminated by PFAS from AFFF use at nearby fire training areas. Our proposal includes a combination of required elements according to ATSDR’s protocol and novel components, such as applying total extractable organofluorine (EOF) and non-targeted screening methods to provide a more complete assessment of PFAS exposures and analyzing lipoprotein fractions, body fat measurements, and metabolomics markers of lipid metabolism. Research partners include Silent Spring Institute, Harvard T.H. Chan School of Public Health, and Eastern Research Group, and community partner organizations include Massachusetts Breast Cancer Coalition (MBCC) in Hyannis and People of Ayer Concerned about the Environment (PACE). The primary aims are: Aim 1. Evaluate serum-PFAS levels, serum biomarkers of effects, and neurobehavioral outcomes in 1,000 adults and 350 children in two communities with AFFF contamination of public water supplies. Aim 2. Measure total extractable organofluorine and non-targeted PFAS profiles in blood samples from children and adults to provide a more complete assessment of total PFAS exposures. Aim 3. Evaluate associations between measured and estimated PFAS exposures and markers of elevated disease risks, such as lipoprotein subfractions, metabolomics markers of lipid metabolism, body fat measurements, and antibody concentrations.

抽象的 在美国，已经发现越来越多的饮用水被污染 每氟烷基物质（PFA）。我们首先发现22个州至少有600万美国人 从超过EPA的2016年PFO和PFOA指南的来源获得饮用水，超过100 据估计，有百万美国人的自来水中有PFA。超过400个DOD站点已知或 可疑的PFA版本。我们的团队发现，靠近军事消防训练区和机场 预测由于使用含PFA的水性膜形成泡沫（AFFF）而导致的饮用水污染 液体燃料发射。与PFOA和PFO有关的健康问题包括癌症，肝毒性，高胆固醇和 生殖和发育效果。遵循我们关于免疫毒性的第一份报告，2016年国家 毒理学计划系统评价得出的结论是，PFO和PFOA都是免疫危害的 给人类。虽然总胆固醇升高与PFAS暴露有关，但我们的初步 有证据表明与预测心血管风险的特异性脂蛋白亚分射的关联 疾病。尽管有越来越多的PFA暴露的社区数量很少 患有PFAS影响的饮用水社区的流行病学研究。 作为ATSDR的多站点研究的一部分，对与PFA污染有关 饮用水，我们建议对马萨诸塞州东部两个社区的PFAS健康影响进行研究 在附近的消防训练中，PFA污染了公共饮用水供应 区域。我们的建议包括根据ATSDR协议和新颖的必需元素组合 组件，例如应用总可提取器官氟氨酸（EOF）和非目标筛选方法 提供对PFA暴露和分析脂蛋白分数的更完整评估 脂质代谢的测量和代谢组学标记。研究合作伙伴包括寂静的春天 哈佛大学研究所陈公共卫生学院和东方研究小组和社区合作伙伴 组织包括Hyannis的马萨诸塞州乳腺癌联盟（MBCC）和艾尔人 关注环境（速度）。主要目的是： AIM 1。评估血清-PFA水平，效果的血清生物标志物和神经行为结局 两个社区中有1,000名成人和350名儿童对公共供水污染。 AIM 2。测量血液样本中的总可提取器官氟和非靶向的PFA 从儿童和成人那里提供对PFA总暴露的更完整评估。 目标3。评估测量和估计的PFA暴露与标记之间的关联 疾病升高的风险，例如脂蛋白亚构件，脂质代谢的代谢标记， 体内脂肪测量和抗体浓度。