MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS

母胎医学单位的多中心网络

• 批准号: 6331393
• 负责人: YORAM SOROKIN
• 金额: $ 122.82万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6331393
• 关键词: clinical trials; cooperative study; disease /disorder proneness /risk; embryo /fetus disorder; female; human pregnant subject; human subject; human therapy evaluation; mother /infant health care; neonatal intensive care; newborn human (0-6 weeks); obstetrics; patient oriented research; pediatrics; perinatal; pregnancy; pregnancy disorder; premature infant human; prenatal care; prenatal diagnosis; women's health

Our overall goal is to improve the health of pregnant women, their fetuses, and neonates. The objective of this application is to continue the Maternal-Fetal Medicine Unit (MFMU) Clinical Center at Wayne State University. We are committed to cooperative research and offer a large patient base (13,000 deliveries/year), including a high percentage of minorities, from which to enroll into network protocols. We propose to achieve this objective by documenting that Wayne State's spectrum of research expertise and resources is consistent with continuing our successful participation in the Network; our capability and intent of recruitment, rigorous patient evaluations and treatment of subjects using common protocols are documented by both current status and past performance. It is our expectation that we will continue to be an integral and contributing member of the MFMU in research identified by other members and as innovators of new projects; the concept protocol is a clinical trial aimed at prevention of preterm delivery. Twelve subspecialists in maternal-fetal medicine (one also subspecialized in clinical genetics), and two neonatologists will collaborate in the MFMU Network Center. Additional research faculty in the Department of Obstetrics and Gynecology, and other departments will provide support as needed Seven experienced research nurses are currently employed to accomplish network protocols. The Division of Neonatology is also submitting their Neonatal Network Grant renewal proposal and continues to collaborate closely with the MFMU Network. Our computerized perinatal database now contains over 110,000 deliveries. One of our long-range research goals is to develop strategies for the prevention of preterm birth. The speck objective of our concept protocol is to reduce the rate of spontaneous preterm birth (SPTB) less than 32 weeks' gestation. The central hypothesis of the proposed research is that midtrimester antibiotic treatment of women found to be at increased risk for early SPTB will reduce preterm delivery at less than 32 weeks, lengthening gestation. The specific aims are to select pregnant women at increased risk for SPTB less than 32 weeks, and to establish the efficacy of antibiotic treatment in reduction of SPTB less than 32 weeks of gestation. The proposed research is innovative because the antibiotic treatment is given to women at risk for early SPTB selected by a discriminating multiple serum marker screening. The outcomes will be significant because they will provide a strong foundation for midtrimester antibiotic treatment of women identified to be at risk for SPTB less than 32 weeks, and thereby reduction of perinatal morbidity and mortality.

我们的总体目标是改善孕妇、她们的健康 胎儿和新生儿。该应用程序的目的是继续 韦恩州立大学母婴医学中心 (MFMU) 临床中心 大学。我们致力于合作研究并提供大量 患者群体（每年 13,000 次分娩），其中很大一部分是 少数群体，从中注册网络协议。我们建议 通过记录韦恩州立大学的频谱来实现这一目标 研究专业知识和资源与继续我们的研究是一致的 成功参与网络；我们的能力和意图 招募、严格的患者评估和受试者治疗 通用协议由当前状态和过去记录 表现。我们期望我们将继续成为一个不可或缺的整体 以及 MFMU 在其他机构确定的研究中做出贡献的成员 成员和新项目的创新者；概念协议是 旨在预防早产的临床试验。十二 母胎医学亚专科医师（其中一名还专科于 临床遗传学），两名新生儿学家将在 MFMU 合作 网络中心。系的其他研究人员 妇产科等科室将提供支持 根据需要 目前雇用七名经验丰富的研究护士 完成网络协议。新生儿科也 提交新生儿网络补助金更新提案，并 继续与 MFMU 网络密切合作。我们的 计算机化的围产期数据库现在包含超过 110,000 次分娩。 我们的长期研究目标之一是制定战略 预防早产。我们概念协议的斑点目标 是将自发性早产率（SPTB）降低到32以下 怀孕几周。拟议研究的中心假设是 孕中期女性接受抗生素治疗的风险增加 早期 SPTB 将减少 32 周以内的早产， 延长妊娠期。具体目标是选择孕妇 32 周内 SPTB 风险增加，并确定疗效 抗生素治疗在 32 周内减少 SPTB 的效果 妊娠。拟议的研究具有创新性，因为抗生素 由专家选出的有早期 SPTB 风险的女性接受治疗 区分多种血清标志物筛查。结果将是 意义重大，因为它们将为 对被确定有风险的女性进行中期抗生素治疗 SPTB 小于 32 周，从而降低围产期发病率 和死亡率。