ANTHRAX MOLECULAR EVOLUTION, DIVERSITY AND EPIDEMIOLOGY

炭疽分子进化、多样性和流行病学

• 批准号: 6636398
• 负责人: Paul Stephen Keim
• 金额: $ 29.03万
• 依托单位: NORTHERN ARIZONA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6636398
• 关键词: Bacillus anthracis; RNase protection assay; alleles; anthrax; bacterial genetics; biochemical evolution; computer simulation; disease outbreaks; ecology; gene expression; gene mutation; genetic markers; genetic polymorphism; geographic site; host organism interaction; linkage mapping; mathematical model; microorganism classification; molecular genetics; northern blottings; nucleic acid repetitive sequence

DESCRIPTION (Adapted from the Applicant's Abstract): The overall goal of this study is to link the molecular genetic evolution of Bacillus anthracis to epidemiological models of North American and African anthrax in an effort to better understand the geographic, biotic, and abiotic conditions responsible for outbreaks of anthrax in the world at large and the sources of this pathogen. Towards this end, Dr. Keim and his collaborators will: (1) study the genetic-molecular epidemiology of Bacillus anthracis isolated from different geographic locations and habitats, (2) ascertain the different factors (parameters) that affect the distribution of the molecular markers they employ in their epidemiology surveys and estimate the values of these parameters in laboratory culture. (3) Using Monte Carlo simulations, they will ascertain how the distribution of these markers within and between populations of Bacillus anthracis will be affected by geographic, genetic and ecological processes.

描述（根据申请人的摘要改编）： 研究是将炭疽芽孢杆菌的分子遗传进化联系起来 北美和非洲炭疽的流行病学模型，以 更好地了解负责的地理，生物和非生物条件 为了全面发生炭疽病的爆发， 病原。为此，Keim博士和他的合作者将：（1）研究 从中分离出的炭疽芽孢杆菌的遗传分子流行病学 不同的地理位置和栖息地，（2）确定不同的地理位置 影响分子标记分布的因素（参数） 他们在流行病学调查中采用并估计这些价值 实验室文化中的参数。 （3）使用蒙特卡洛模拟，他们将 确定这些标记在之间的分布如何 炭疽芽孢杆菌的种群将受地理，遗传和 生态过程。

项目成果

vrrB, a hypervariable open reading frame in Bacillus anthracis.

vrrB，炭疽杆菌中的高变开放阅读框。

• DOI: 10.1128/jb.182.14.3989-3997.2000
• 发表时间: 2000
• 期刊: Journal of bacteriology
• 影响因子: 3.2
• 作者: Schupp,JM;Klevytska,AM;Zinser,G;Price,LB;Keim,P
• 通讯作者: Keim,P

Humans and evolutionary and ecological forces shaped the phylogeography of recently emerged diseases.

• DOI: 10.1038/nrmicro2219
• 发表时间: 2009-11
• 期刊: Nature reviews. Microbiology

Bacillus anthracis incident, Kameido, Tokyo, 1993.

• DOI: 10.3201/eid1001.030238
• 发表时间: 2004-01
• 期刊: Emerging infectious diseases
• 影响因子: 11.8
• 作者: Takahashi H;Keim P;Kaufmann AF;Keys C;Smith KL;Taniguchi K;Inouye S;Kurata T
• 通讯作者: Kurata T

Pre-Columbian origins for North American anthrax.

• DOI: 10.1371/journal.pone.0004813
• 发表时间: 2009
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kenefic LJ;Pearson T;Okinaka RT;Schupp JM;Wagner DM;Hoffmaster AR;Trim CB;Chung WK;Beaudry JA;Jiang L;Gajer P;Foster JT;Mead JI;Ravel J;Keim P
• 通讯作者: Keim P