Career training in bladder control neural protheses

膀胱控制神经假体的职业培训

• 批准号: 6320682
• 负责人: Kenneth J. Gustafson
• 金额: $ 10.39万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6320682
• 关键词: assistive device /technology; bioengineering /biomedical engineering; biomedical equipment development; cats; electronic stimulator; electrophysiology; human subject; medical implant science; nervous system prosthesis; patient oriented research; rehabilitation; spinal cord injury; urinary incontinence; urinary tract prosthesis

DESCRIPTION (Adapted from Application's Description): Dr. Gustafson is an engineer committed to establishing a career in applied neurophysiology research and development of neural prosthetic devices to restore function in individuals with neurological disorders. His short-term career goals are to develop solid foundations in electrophysiological experimental techniques, neural prostheses, genitourinary anatomy and current medical practices. The proposed career development plan will train Dr. Gustafson in 1) electrophysiological experimental techniques and neuroprostheses; 2) genitourinary-related anatomy, physiology and medical practices, and rehabilitative issues for individuals with spinal cord injury (SCI); and 3) independent career development and translational research. Mentors at Case Western Reserve University (CWRU), MetroHealth Medical Center (MHMC) and the Cleveland Functional Electrical Stimulation Center (FESC) will provide training and expertise, and monitor and support Dr. Gustafson's career advancement. The existing collaborative nature of this research and training environment is suited to the multi-disciplinary nature of the project and Dr. Gustafson's career goals in biomedical research. In addition to didactic instruction and structured clinical training, parallel research projects in both animals and humans with SCI are integrated into the career development plan. The research plan will investigate the underlying neurophysiology involved in control of continence and micturition using selective electrical recording and stimulation of individual nerve fascicles of the pudendal nerve. First, the individual pudendal nerve branches that allow the greatest efficacy to sense the onset of reflex bladder contractions, abolish reflex bladder contractions and elicit coordinated micturition will be identified. Second, selective control of these 3 functions with a single nerve cuff placed on the pudendal nerve will be examined. Anatomical cadaver studies and finite element modeling will be combined to evaluate and improve device selectivity. Loss of bladder control is a significant problem in individuals with neurological disorders and SCI; development of an effective, peripherally located neuroprosthesis would significantly improve clinical options for these individuals. This career development plan will establish Dr. Gustafson as an independent investigator in biomedical research and prepare him to lead research efforts in the development of neural prostheses.

描述（改编自应用程序的描述）：Gustafson 博士是一位 工程师致力于建立应用神经生理学的职业生涯 研究和开发神经假体装置以恢复功能 患有神经系统疾病的人。 他的短期职业目标是 为电生理实验技术奠定坚实的基础， 神经假体、泌尿生殖系统解剖学和当前的医疗实践。 拟议的职业发展计划将对 Gustafson 博士进行以下方面的培训：1) 电生理实验技术和神经假体； 2） 泌尿生殖相关的解剖学、生理学和医疗实践，以及 脊髓损伤（SCI）患者的康复问题；和 3) 独立的职业发展和转化研究。案例导师 西储大学 (CWRU)、MetroHealth 医疗中心 (MHMC) 和 克利夫兰功能性电刺激中心 (FESC) 将提供 培训和专业知识，并监督和支持古斯塔夫森博士的职业生涯 进步。 本研究和培训现有的协作性质 环境适合项目的多学科性质，并且 古斯塔夫森博士在生物医学研究方面的职业目标。 除了教学指导和结构化临床培训之外，并行 SCI 动物和人类研究项目被纳入 职业发展计划。该研究计划将调查潜在的 神经生理学涉及控制节制和排尿使用 个体神经束的选择性电记录和刺激 阴部神经。 首先，个别阴部神经分支 允许最大的功效来感知反射性膀胱收缩的开始， 消除膀胱反射性收缩并引起协调排尿 确定。二、用单根神经选择性控制这3种功能 将袖带放置在阴部神经上进行检查。 解剖尸体 研究和有限元建模将结合起来评估和改进 设备选择性。 膀胱失控是一个严重的问题 患有神经系统疾病和 SCI 的个体；发展有效的、 位于外周的神经假体将显着改善临床 这些人的选择。 本职业发展计划将建立 古斯塔夫森博士作为生物医学研究的独立调查员 帮助他做好领导神经假体开发研究工作的准备。