INTL POPULATION STUDY ON MACRONUTRIENTS AND BP INTERMAP

关于常量营养素和血压互图的国际人口研究

• 批准号: 6728911
• 负责人: JEREMIAH STAMLER
• 金额: $ 3.15万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6728911
• 关键词: American; British; Chinese; Japanese; antioxidants; caffeine; cardiovascular disorder epidemiology; clinical research; creatinine; dietary calcium; dietary carbohydrates; dietary fiber; dietary lipid; dietary proteins; education; human middle age (35-64); human subject; hypertension; international cooperation; magnesium; nutrition related tag; potassium; racial /ethnic difference; socioeconomics; sodium

DESCRIPTION: (Adapted from Investigator's Abstract) This application requests support for further testing of study hypotheses and exploratory analyses in the international cooperative INTERMAP Study, a basic epidemiologic investigation designed to help clarify unanswered questions on the role of dietary factors, particularly macronutrients, in the etiology of unfavorable blood pressure (BP) levels prevailing for a majority of middle-aged and older individuals in the U.S. population. A particular focus within the context of this overall objective is to help elucidate the role of these dietary factors in accounting for the even more adverse BP patterns of less educated population strata, e.g., in the U.S. for less educated African-Americans, Hispanics, and Whites. INTERMAP aims to achieve a major advance on these important issues, based on its design: a large sample size of 4,700 men and women ages 40 to 59 years of age from 17 diverse population samples of varied ethnicity, socioeconomic status (SES), and dietary habits in four countries (China, Japan, UK, and the U.S.). Efficiency has been assured by major cost-sharing by non-U.S. centers, so that resources requested have been much less than for research of this scope done solely in the U.S. Specific aims involve elucidating influences on BP of amount and type of protein, lipids, carbohydrates, also amino acids, Ca, Mg, antioxidants, fiber, and caffeine. Primary hypotheses to be tested, with control for BMI, intake of alcohol, Na, K, age, sex, and other confounders are as follow: dietary protein is inversely related to BP; inverse relations between education and BP are significantly accounted for by education-correlated differences in dietary protein intake; there is a direct relation to BP of dietary SFA, cholesterol, Keys score, starch; there is an inverse relation of PFA and of P/S. Participants, randomly selected, provided two timed 24-hr urine collections for assessment of Na, K, creatinine, urea, and completed four 24-hr dietary recalls. BP was measured twice at each of four clinic visits. The study has been coordinated by two Coordinating Centers -- Northwestern University, Chicago and Imperial College of Medicine, London. Urinary determinations were made at a Central Laboratory in Leuven, Belgium. The 24-hr dietary recalls have been converted into nutrients with use in each country of an up-to-date, extensive, high quality, well maintained national data base, with international study-wide standardization and quality control. Findings on relations of multiple dietary factors to BP are to be used to estimate favorable impact on BP of multiple improvements in nutrition by populations. The investigators point out that this, in turn, should aid in enhancing dietary recommendations toward achieving the goal of primary prevention of hypertension, and shifting BP distributions downward to avoid excess risk associated with present levels, generally above optimal.

描述：（根据调查员的摘要进行了改编）此应用程序请求 支持进一步测试研究假设和探索性分析 国际合作Intermap研究，基本的流行病学研究 旨在帮助阐明有关饮食因素的作用的未解决问题， 特别是大量营养素，在不利血压（BP）的病因学中 在大多数中年和年龄较大的人中占上风的水平 美国人口。在整个整体背景下的特别重点 目的是帮助阐明这些饮食因素在会计中的作用 对于受过教育程度较低的人口阶层的BP模式更加不利，例如 在美国，有教育程度较低的非裔美国人，西班牙裔和白人。 Intermap旨在基于这些重要问题的重大进步 其设计：大型样本量为4,700名40至59岁的男女 年龄来自17种不同种族，社会经济的种类样本 四个国家（中国，日本，英国和 我们。）。非美国中心的主要成本分担确保了效率， 因此，所要求的资源比对此范围的研究要少得多 仅在美国的特定目标中完成的目的涉及阐明对BP的影响 蛋白质，脂质，碳水化合物的量和类型，也是氨基酸，CA，MG， 抗氧化剂，纤维和咖啡因。主要假设要测试， 控制BMI，酒精，NA，K，年龄，性别和其他混杂因素的控制是 如下：饮食蛋白与BP成反比；逆关系 在教育和BP之间，由 饮食蛋白摄入量与教育相关的差异；有一个直接的 与饮食SFA，胆固醇，键评分，淀粉的BP有关；有一个 PFA和P/S的逆关系。随机选择的参与者 两个定时的24小时尿液收集，用于评估Na，K，肌酐，尿素， 并完成了四次24小时饮食召回。 BP在四个中测量了两次 诊所就诊。该研究由两个协调中心协调 - 西北大学，芝加哥和伦敦帝国医学院。 在比利时鲁汶的一个中央实验室进行尿测定。 24小时的饮食召回已转化为每种用途的营养 最新，广泛，高质量，维护良好的国家 数据库，具有国际学习范围的标准化和质量控制。 关于多种饮食因素与BP的关系的发现应用于 估计对BP的有利影响，从而通过 人群。调查人员指出，这又应该有助于 增强饮食建议实现主要目标 预防高血压和向下移动BP分布以避免 与当前水平相关的多余风险，通常高于最佳。