RENOV ANIMAL FACIL: SIV ENVELOPE GLYCOPROTEIN, AIDS VACCINE

RENOV 动物设施：SIV 包膜糖蛋白、艾滋病疫苗

• 批准号: 6794419
• 负责人: JOAN F. LORDEN
• 金额: $ 50万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6794419
• 关键词: AIDS vaccines; Primates; animal colony; biomedical facility; building /facility design /renovation; disease /disorder; dogs; glycoproteins; imaging /visualization /scanning; simian immunodeficiency virus; surgery

Regarding AIDS: DESCRIPTION (provided by applicant): This application requests matching funds for Phase II of the renovation of the VH Animal Facility at the UAB. VH was completed in 1971, and remains the largest research building at UAB. The 35,438 sq. ft. assigned to the Animal Resources Program in the basement of VH is the largest of the UAB animal facilities. It currently houses over 15,000 animals, and provides housing and support services for 30 percent of the animal population at UAB, representing 14 species including rodents, dogs, farm animals, and non-human primates (NHP). This application proposes to renovate and expand animal research support space for surgery and imaging large and small animal species. It also proposes to consolidate central support service space. It will replace one of four air handlers that serve this facility, relocate the cage wash system, and improve adjacencies of many support areas near the loading dock, lead to improved traffic flow, improve security, ventilation, and plumbing, and abate asbestos. UAB is committed to the prevention and treatment of diseases as prioritized in the "Healthy People 2010" directive. The investigators at UAB that will directly benefit from this application have diverse research interests that include heart disease, cancer, diabetes, gene therapy, chemoprevention, vaccine development and delivery, neural processing of visual stimulus and memory, and the mechanisms responsible for immune responses. The proposed renovations will thus provide state-of-the-art animal facilities to support federally-funded research in areas emerging as high priorities for new therapeutic strategies and health maintenance.

关于艾滋病： 说明（由申请人提供）： 本申请要求为 UAB 的 VH 动物设施改造第二阶段提供配套资金。 VH 于 1971 年竣工，至今仍是阿拉巴马大学最大的研究大楼。 VH 地下室的动物资源计划占地 35,438 平方英尺，是 UAB 最大的动物设施。它目前饲养着 15,000 多只动物，为 UAB 30% 的动物种群提供饲养和支持服务，这些动物包括啮齿动物、狗、农场动物和非人类灵长类动物 (NHP) 等 14 个物种。该申请旨在翻新和扩大大型和小型动物物种手术和成像的动物研究支持空间。它还建议巩固中央支持服务空间。它将取代为该设施服务的四个空气处理机之一，重新定位笼式清洗系统，并改善装卸码头附近许多支持区域的邻接关系，从而改善交通流量，改善安全性、通风和管道系统，并减少石棉。 UAB致力于“健康人民2010”指令中优先预防和治疗的疾病。将直接受益于该应用的 UAB 研究人员拥有多种研究兴趣，包括心脏病、癌症、糖尿病、基因治疗、化学预防、疫苗开发和交付、视觉刺激和记忆的神经处理以及负责免疫反应的机制。因此，拟议的翻新工程将提供最先进的动物设施，以支持联邦政府资助的新治疗策略和健康维护高度优先领域的研究。