Quantitative MR Imaging and Spectroscopy in Alcoholism

定量 MR 成像和光谱学在酒精中毒中的应用

• 批准号: 6620754
• 负责人: GRAEME F. MASON
• 金额: $ 9.37万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6620754
• 关键词: age difference; alcoholism /alcohol abuse; bioenergetics; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain metabolism; cognition; drug withdrawal; electrophysiology; functional ability; gamma aminobutyrate; gender difference; glucose metabolism; glutamates; human subject; laboratory rat; magnetic resonance imaging; mathematical model; microdialysis; model design /development; neural transmission; neuropharmacology; nuclear magnetic resonance spectroscopy; patient oriented research; postdoctoral investigator; prefrontal lobe /cortex; psychological tests

Magnetic resonance spectroscopy (MRS) and imaging (MRI) allow studies of brain amino acid neurotransmitters in vivo. Recent developments of MR permit not only measurements of neurotransmitter levels, but of synthesis and release, also. The technique is enhanced by the candidate's use of mathematics to interpret measurements quantitatively. The candidate applied an unusual background in MRS, MRI, math, and neurochemistry to alcoholism and (2) improve his education in pharmacology, diagnosis, and treatment of alcoholism. The program will combine MR with other measurements to study neurotransmission and energetics, improve mathematical models of neurotransmission and metabolism, and apply them to pharmacology of alcoholism. His other long term goal is dissemination of MR methods and mathematics for study design and interpretation. The leaders of Psychiatry at Yale have deliberately fostered integration of basic and clinical research, and they have invested heavily in MR research. For education and collaboration with the candidate, there are NIAAA and VA Alcohol Research Centers and laboratories and faculty who are well-established in the field of alcoholism. The grant will free the candidate from other commitments so that he can focus on learning about and researching alcoholism. The development plan has three parts: (1) Education in diagnosis, treatment, neurochemistry, and pathophysiology of alcoholism, (2) Research for more detailed knowledge of pathways of neurotransmitter metabolism, clinical correlates of the basic data, and validation of models of neurotransmission. Two projects are proposed. (1) Measure rates of brain glutamate neurotransmission and glucose utilization in alcohol-dependent patients during detoxification, testing for correlations of those parameters with each other and with measures of cognitive function and electrophysiology, which is funded through the NIAAA Center for Translational Neuroscience in Alcoholism (CTNA) at Yale. (2) Validate and further develop the mathematical models of glutamate and GABA neurotransmission, combining measurements of isotopic labeling in rats with microdialysis measurements of ECF levels of brain glutamate, glutamine, and GABA.

磁共振波谱 (MRS) 和成像 (MRI) 可以在体内研究大脑氨基酸神经递质。 MR 的最新发展不仅可以测量神经递质水平，还可以测量神经递质的合成和释放。考生使用数学来定量解释测量结果，从而增强了该技术。该候选人将 MRS、MRI、数学和神经化学方面的不同寻常的背景应用于酒精中毒的研究，并且 (2) 提高了他在酒精中毒的药理学、诊断和治疗方面的教育。该项目将把MR与其他测量结合起来，研究神经传递和能量学，改进神经传递和代谢的数学模型，并将其应用于酒精中毒的药理学。他的另一个长期目标是传播用于研究设计和解释的 MR 方法和数学。耶鲁大学精神病学的领导者有意促进基础研究和临床研究的结合，并在 MR 研究上投入了大量资金。为了与候选人进行教育和合作，NIAAA 和 VA 酒精研究中心和实验室以及在酗酒领域颇有建树的教职人员。这笔赠款将使候选人摆脱其他承诺，以便他可以专注于了解和研究酗酒。该发展计划分为三个部分：（1）酒精中毒诊断、治疗、神经化学和病理生理学方面的教育，（2）研究神经递质代谢途径的更详细知识、基础数据的临床相关性以及神经传递模型的验证。提出了两个项目。 (1) 测量酒精依赖患者在戒毒期间的大脑谷氨酸神经传递和葡萄糖利用率，测试这些参数之间的相关性以及与认知功能和电生理学测量的相关性，该项目由 NIAAA 酒精中毒转化神经科学中心资助（CTNA）在耶鲁大学。 (2) 将大鼠同位素标记测量与脑谷氨酸、谷氨酰胺和 GABA ECF 水平的微透析测量相结合，验证并进一步开发谷氨酸和 GABA 神经传递的数学模型。