MRS OF PATS W/ AIDS DEMENTIA COMPLEX: MULTICENTER ACTG 301 DRUG EVAL PROGRAM

患有艾滋病痴呆症的 PATS 夫人：多中心 ACTG 301 药物评估计划

• 批准号: 6657668
• 负责人: KIM M CECIL
• 金额: $ 22.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6657668
• 关键词: biomedical resource; enzymes; musculoskeletal system

Inactivity or disuse as a result of immobilization, bed rest, non-weight bearing, or denervation causes many adaptive changes in skeletal muscle with muscular dysfunction as a final outcome. Loss of muscle mass or muscular atrophy is one of the most recognized consequences of disuse. Inactivity has also been shown to cause metabolic alterations in skeletal muscle, the most important being elevated basal inorganic phosphate (Pi). We have tracked 10 subjects through an 8 week period of cast immobilization of the lower leg followed by ten weeks of rehabilitation. For comparison of changes seen during rehabilitation, we have performed similar testing on 7 control subjects over a ten week period. Immobilization of the ten subjects resulted in skeletal muscle atrophy, an increase in basal inorganic phosphate and decreased force production. 31P NMR was used to show a 43% increase in basal inorganic phosphate in the atrophy group as compared with the control population. The maximum cross-sectional area of the triceps surae was seen to decrease as well. The extent of force loss was greater than the decrease in muscle cross-sectional area, meaning that the atrophic, disused muscle had become less efficient at producing force as compared to control subjects with similar muscle CSAs. Regression analysis of both atrophy and control measurements of MaxCSA versus Force proved statistically significant with the atrophy group generating lower forces at similar MaxCSAs (R2=0.55 in the atrophy group, and 0.70 in the control). Throughout recovery the muscular efficiency in the atrophy group was seen to increase approaching control values at the end of the rehab period. This was accomplished by an increase in Force, maximum CSA, and a decrease in basal inorganic phosphate. The change in muscular efficiency as a result of immobilization, where the extent of force loss and muscle function exceeded the decrease in muscle size suggests that there are other significant factors caused by immobilization that lead to an overall loss in muscul ar efficiency besides muscle atrophy. We believe elevated inorganic phosphate, along with a decrease in muscle size, to be an important contributor to decreased muscle function following immobilization.

由于固定，床休息而导致的无活动或失业， 非重量轴承或去神经导致许多自适应变化 具有肌肉功能障碍的骨骼肌作为最终结果。 损失 肌肉质量或肌肉萎缩是最公认的 废弃的后果。 也已证明无效 骨骼肌的代谢改变，最重要的是 基底磷酸盐（PI）升高。 我们已经跟踪了10个主题 在8周的铸造固定期间 其次是康复十个星期。 用于比较变化 在康复期间看到，我们对7进行了类似的测试 在十个星期内的控制对象。 十个受试者的固定化导致骨骼肌 萎缩，基础无机磷酸盐的增加和力降低 生产。 31p NMR用于显示基础增长43％ 与对照相比，萎缩基的无机磷酸盐 人口。 三头肌的最大横截面是 看到也减少。 施力损失程度大于减少 肌肉横截面区域，这意味着萎缩，废弃的肌肉 与对照相比，产生力的效率降低了 具有类似肌肉CSA的受试者。 两者的回归分析 MAXCSA与力的萎缩和控制测量结果证明 与萎缩群产生较低的统计学意义 相似的maxcsas的力（萎缩组的R2 = 0.55，0.70 IN 控件）。 在整个恢复过程中 发现萎缩群增加了接近的控制值 康复期结束。 这是通过增加而实现的 力，最大CSA和基础无机磷酸盐的降低。 这 由于固定而变化肌肉效率，其中 力量损失和肌肉功能的程度超过了下降 肌肉大小表明还有其他重要因素 通过固定化导致肌肉效率的总体损失 除了肌肉萎缩。 我们认为升高无机磷酸盐， 随着肌肉大小的减小，成为重要的贡献者 固定后肌肉功能降低。