HIGH RESOLUTION PROTON MR SPECTROSCOPY OF HIV INFECTED PATIENTS

HIV 感染患者的高分辨率质子磁共振波谱检查

• 批准号: 6495478
• 负责人: KIM M CECIL
• 金额: $ 22.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6495478
• 关键词: aging; biomedical resource; enzymes; female; human subject; musculoskeletal system; technology /technique

The purpose of this study was to develop new methodologies to measure muscle metabolism and blood flow in older humans, both with normal and reduced blood flow (peripheral vascular disease). Progress in this year was testing of a method using partial cuff ischemia during recovery from submaximal exercise. With MRS, we measure PCr recovery with a blood pressure cuff (positioned on the upper leg) inflated to 0, 50, 60, 70, and 90 mmHg. Similar measurements are made using duplex Doppler to determine the relative effect of the partial cuff pressures on muscle blood flow. NIRS measurements of oxygen saturation were collected during both MRS and Doppler measurements. Preliminary results suggest normal subjects have no impairment in PCr recovery with flow reductions up to 25%. With greater flow reductions, both flow and PCr recovery are impaired. Significant correlations were found between NIRS recovery and peak Doppler flow after ischemia in patients with mild PVD. Acceptab le levels of reproducibility suggest additional data will allow mathematical determination of relative contributions of blood flow and mitochondrial capacity in determining muscle metabolism in elderly healthy and diseased subjects.

这项研究的目的是开发新方法 测量年龄较大的人的肌肉代谢和血流 正常和减少的血液（周围血管疾病）。 进步 在今年正在使用部分袖口缺血测试一种方法 从次最大运动恢复期间。 使用MRS，我们测量PCR 用血压袖带恢复（位于上腿） 充气至0、50、60、70和90 mmHg。 进行类似的测量 使用双工多普勒确定部分的相对效果 袖口压力在肌肉血流上。 氧气测量值 在MRS和多普勒测量过程中都收集饱和度。 初步结果表明正常受试者在PCR中没有损害 恢复流量减少高达25％。 流动更大 减少，流量和PCR恢复都受损。 重要的 发现NIRS恢复与峰值多普勒流量之间的相关性 轻度PVD患者缺血后。 接受水平 可重复性建议其他数据将允许数学 确定血流的相对贡献和 线粒体能力确定老年人的肌肉代谢 健康和患病的受试者。