Medication Adherence in Depressed Coronary Patients

抑郁性冠心病患者的药物依从性

• 批准号: 6649049
• 负责人: Donald C Haas
• 金额: $ 2.77万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-27 至 2006-01-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6649049
• 关键词: aspirin; behavioral /social science research tag; cardiovascular disorder epidemiology; cardiovascular disorder risk; clinical research; comorbidity; coronary disorder; depression; heart disorder chemotherapy; human subject; longitudinal human study; monitoring device; postdoctoral investigator; psychotherapy; relapse /recurrence; therapy compliance

DESCRIPTION (provided by applicant): Depression has been consistently shown to be a strong, independent risk factor for recurrent acute coronary syndromes (ACS). The mechanisms through which depression mediates this excess risk, however, remain unclear. Depressed patients with co-morbid chronic medical illness are less adherent to their prescribed medications, suggesting that non-adherence to medications may, at least partly, explain the excessive recurrence rate of ACS in depressed coronary patients. The hypothesis that depressed coronary patients are less adherent to prescribed medications than non-depressed coronary patients will be tested. Specifically, using a prospective case-control design of patients admitted for ACS (N=136), daily adherence with prescribed aspirin therapy will be monitored upon discharge utilizing a medication event monitoring system (MEMS) for 16 weeks. A secondary hypothesis will explore whether depression treatment in depressed coronary patients improves adherence compared to depressed coronary patients not treated for depression. Beyond investigating the depression-ACS relation, determining whether depressed coronary patients are less adherent with medications may identify a high-risk clinical population in whom intervention may be warranted.

描述（由申请人提供）：抑郁症一直被证明是复发性急性冠状动脉综合征（ACS）的一个强大的、独立的危险因素。然而，抑郁症介导这种过度风险的机制仍不清楚。患有慢性疾病的抑郁症患者对处方药物的依从性较差，这表明不遵守药物治疗可能至少部分解释了抑郁性冠心病患者 ACS 复发率过高的原因。抑郁性冠心病患者比非抑郁性冠心病患者对处方药物的依从性较差的假设将得到检验。具体来说，对因 ACS 入院的患者 (N=136) 采用前瞻性病例对照设计，出院后将使用药物事件监测系统 (MEMS) 监测每日服用处方阿司匹林治疗的情况，持续 16 周。第二个假设将探讨与未接受抑郁治疗的抑郁性冠心病患者相比，抑郁症治疗是否可以提高抑郁性冠心病患者的依从性。除了研究抑郁症与 ACS 的关系之外，确定冠心病抑郁症患者对药物的依从性是否较差，可能会识别出可能需要干预的高危临床人群。

项目成果

Depression and disability in coronary patients: time to focus on quality of life as an end point.

冠心病患者的抑郁和残疾：是时候关注生活质量作为终点了。

• DOI: 10.1136/hrt.2005.066035
• 发表时间: 2006
• 期刊: Heart (British Cardiac Society)
• 作者: Haas,DC