Epidemiology of Venous Thromboembolism

静脉血栓栓塞的流行病学

• 批准号: 6773942
• 负责人: Robert J Glynn
• 金额: $ 31.5万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6773942
• 关键词: alcoholic beverage consumption; aspirin; autoantibody; behavioral /social science research tag; biochemistry; biomarker; body composition; body physical activity; cancer risk; cardiovascular disorder epidemiology; clinical research; clinical trials; gene environment interaction; genetic polymorphism; genetic susceptibility; homocystinuria; hormone therapy; human data; human tissue; lifestyle; longitudinal human study; myocardial infarction; pulmonary circulation obstruction; relapse /recurrence; smoking; thromboembolism; tobacco abuse; venous thrombosis

Venous thromboembolism (VTE) is a common condition causing substantial morbidity, cost and mortality, yet several aspects of the epidemiology of this disease remain unexplored. The major aim of this proposal is to evaluate potentially modifiable lifestyle predictors of VTE and their joint associations with biochemical and genetic determinants. Studies will identify determinants of both initial occurrence of VTE as well as recurrence among persons with a prior event. The study design is a prospective cohort study of 77,118 persons based on pooling information from four large randomized trials of US health professionals that have collected detailed risk factor information and have used common strategies to prospectively identify and validate cases of VTE. These trials are: Physicians' Health Studies I and II including 29,071 US male physicians, of whom 22,071 have been followed since the initiation of the first trial in 1982; the Women's Health Study including 39,876 female health professionals who will have an average of 10 years of follow-up; and the Women's Antioxidant Cardiovascular Study including 8,171 female health professionals with prevalent cardiovascular disease or at high risk of cardiovascular disease who will have an average of 8 years of follow-up. Archived blood samples were collected from approximately 75 percent of participants at baseline and will be used to assess biochemical and genetic markers of risk including factor V Leiden, the G20210A mutation in the prothrombin gene, hyperhomocysteinemia, and anticardiolipin antibodies. The study will assess the joint association with risk of these markers and potentially modifiable factors including body mass index, hormone replacement therapy, physical activity, and aspirin use. The study population will include over 1,000 incident cases of VTE, including 750 with blood samples. The large size, prospective design, high follow-up rates, detailed and reliable long-term exposure and outcome information, and the availability of blood specimens on a large subgroup, combined with the relatively low cost, make these cohorts a valuable and unique resource for studying determinants of risk of VTE. The results of this work may lead to new strategies for VTE preventio.

静脉血栓栓塞（VTE）是导致大量发病率，成本和死亡率的常见疾病，但该疾病流行病学的几个方面仍未开发。该提案的主要目的是评估VTE的潜在可修改的生活方式预测指标及其与生化和遗传决定因素的共同关联。 研究将确定VTE初始发生的决定因素以及事件发生的人之间的复发。 该研究设计是对77,118人的一项前瞻性队列研究，该研究基于来自美国卫生专业人员的四项大型随机试验的汇总信息，这些信息已收集了详细的风险因素信息，并使用了常见的策略来识别和验证VTE案件。 这些试验是：医师的健康研究I和II，包括29,071名美国男性医生，自1982年首次试验以来，其中已遵循22,071名。妇女健康研究包括39,876名女性卫生专业人员，他们的随访时间为10年；以及女性的抗氧化剂心血管研究，其中包括8,171名患有患心血管疾病的女性卫生专业人员，或患心血管疾病的高风险，他们平均有8年的随访。 从基线上约75％的参与者中收集了存档的血液样本，并将用于评估风险的生化和遗传标志物，包括因子V Leiden，凝血酶蛋白基因中的G20210a突变，高脑皮压状态血压素血压曲和抗核酸脂蛋白抗体。 该研究将评估与这些标记的风险以及可能修改的因素（包括体重指数，激素替代疗法，体育活动和阿司匹林使用）的联合关联。 研究人群将包括1,000多个VTE事件，其中包括750例血样。 大尺寸，前瞻性设计，高后续率，详细且可靠的长期暴露和结果信息以及大型亚组上的血样本的可用性，结合了相对较低的成本，使这些群体成为研究VTE风险决定因素的宝贵而独特的资源。 这项工作的结果可能会导致VTE预防的新策略。