CORE--RESEARCH SUPPORT

核心——研究支持

基本信息

批准号：
6563798
负责人：
Rishab K. Gupta
金额：
$ 7.89万
依托单位：
SAINT JOHN'S CANCER INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-02-14 至 2002-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6563798
关键词：
biomedical facility blood chemistry cancer registry /resource cryopreservation histopathology human tissue melanoma patient /disease registry polymerase chain reaction tissue resource /registry

项目摘要

The Research Support Core is requested for a centralized collection and processing of blood for RT-PCR and for serum and lymphocytes, and tumor tissues for different projected under the overall program. This will be done to promote uniformity in handing and record keeping of the samples that will be received from various centers participating in the trial and from JWCI. Centralized collection and processing of the samples will allow efficient use of materials, reduce the frequency of venipuncture, and allow maintenance of the process uniformly. Procedures will include the following: 1. Serum received from outside centers will be inspected for their physical appearance and tallied with the packing list. After quality control inspection and appropriate logging and record keeping, the samples will be immediately forwarded to the appropriate laboratory in a coded manner. Blood samples received from JWCI will be processed to collect serum which will be inventoried and recorded in the database, and will be distributed to appropriate laboratories. 2. Blood for RT-PCR will be forwarded immediately after receipt to the appropriate laboratory. Appropriate records will be logged in the database. 3. Bloods collected for lymphocytes at JWCI or received from outside patients will be processed centrally in a uniform manner, cyropreserved and archived. 4. Tumor tissues received from JWCI will be processed for cryopreservation. The specimens upon receipt will be checked for accuracy of the information and appropriateness of the forms. To maintain confidentiality, the specimens will be coded and appropriate records maintained at a central location.

研究支持核心需要集中收集和用于 RT-PCR 以及血清和淋巴细胞以及肿瘤的血液处理根据整体方案组织不同的投影。这将是这样做是为了促进样品处理和记录保存的一致性将从参与试验的各个中心收到来自 JWCI。样本的集中收集和处理将允许有效利用材料，减少静脉穿刺频率，以及允许统一维护流程。程序将包括下列的： 1. 从外部中心收到的血清将进行检查外观并与装箱单相符。品质后控制检查和适当的记录和记录保存，样品将立即以编码形式转发至适当的实验室方式。从 JWCI 收到的血液样本将被处理以收集血清将被清点并记录在数据库中，并将分发给适当的实验室。 2. 用于 RT-PCR 的血液将在收到后立即转发至合适的实验室。适当的记录将被记录在数据库。 3. 在 JWCI 采集或从外部采集淋巴细胞的血液患者将被统一集中处理、冷冻保存并存档。 4. 从 JWCI 收到的肿瘤组织将被处理冷冻保存。收到样本后，将检查信息的准确性以及表格的适当性。为了保密，样本将被编码并在中央保存适当的记录地点。