Fatigue Crack Morphology in Cemented Hips

骨水泥髋关节的疲劳裂纹形态

• 批准号: 6512126
• 负责人: AMOS RACE
• 金额: $ 7.6万
• 依托单位: UPSTATE MEDICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-15 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6512126
• 关键词: bioimaging /biomedical imaging; biomaterial evaluation; biomaterial interface interaction; biomedical automation; bone imaging /visualization /scanning; clinical research; femur; hip prosthesis; human tissue; implant; mechanical stress; medical implant science; morphology; musculoskeletal disorder diagnosis; orthopedics; postmortem; technology /technique development; tissue engineering

DESCRIPTION (provided by applicant): The long term objective of this study is to improve understanding of fatigue failure in the cement mantle of Total Hip Replacements (THR). The proposed imaging technique will provide a new direction for research within the ongoing project of definition and control of the mechanical factors that lead to aseptic loosening of cemented THR. Specifically, a three dimensional map of cement crack surfaces, along with associated stem and endosteal bone morphology, will be generated using an automated high-resolution serial grinding and imaging technique. Currently there are two widely used competing design principles for femoral stems: 'taper slip'/'force closure', and 'minimal subsidence'/shape closure'. The proposed technique will be used to compare the response to in vitro fatigue loading of these two stem types. The serial grinding technique will be used in combination with measurements of stem micro-motions, bone quality and degree of cement/bone interdigitation. Pairs of cadaveric femora will be subjected to cyclic 'stair climbing' loads, with contralateral bones receiving 'taper slip' style and 'minimal subsidence' style implants. The effect of fatigue on these stem/cement/femur complexes will be explored by quantifying fatigue crack surfaces and correlating these data with stem micro-motions and the morphology of stem, cement and endosteal bone. The following hypotheses will be tested: 1) that the magnitudes of stem micro-motions are proportional to the quantity of cement mantle fatigue damage; 2) that 'taper slip' and 'minimal subsidence' stem types have different cement fatigue fracture patterns; 3) that subsidence of 'taper slip' stems requires fatigue failure of the cement mantle; 4) that under cyclic loading, permanent subsidence steps of 'taper slip' stems are associated with reductions in cyclic micro-motions. The results of this study will have immediate clinical relevance by enabling surgeons to make more informed decisions concerning which stem type might be most appropriate for each individual patient. The imaging technique will also facilitate development of stem designs to improve longevity of cement mantles. In addition, the crack imaging system will be used in a pilot study of stem/cement/femur complexes recovered at post-mortem. It is anticipated that successful implementation of the imaging technique will facilitate further studies, including the analysis of recovered stem/cement/femur complexes, which will assist with the NIAMS research goal of 'Development and use of an implant retrieval analysis registry to elucidate the mechanisms of failure'.

描述（由申请人提供）：本研究的长期目标是 提高对全髋关节水泥套疲劳失效的认识 替换品（THR）。所提出的成像技术将提供一个新的方向 用于正在进行的定义和控制项目中的研究 导致骨水泥 THR 无菌性松动的机械因素。 具体来说，水泥裂缝表面的三维图，以及 相关的干和骨内膜骨形态，将使用生成 自动化高分辨率连续研磨和成像技术。现在 股骨柄有两种广泛使用的竞争设计原则：“锥度” 滑动'/'力闭合'和'最小沉降'/形状闭合'。拟议的 技术将用于比较体外疲劳负荷的反应 这两种茎类型。串联磨削技术将联合使用 测量骨干微运动、骨质量和骨水泥/骨程度 相互交叉。成对的尸体股骨将受到循环的“楼梯” 攀爬”负载，对侧骨骼接受“锥滑”方式， “最小沉降”式种植体。疲劳对这些的影响 将通过量化疲劳裂纹来探索茎/水泥/股骨复合体 表面并将这些数据与茎微运动和形态相关联 骨干、骨水泥和骨内膜骨。将检验以下假设：1) 茎微运动的幅度与 水泥地幔疲劳损伤； 2）“锥度滑移”和“最小沉降” 阀杆类型具有不同的水泥疲劳断裂模式； 3) 沉降 “锥形滑移”杆需要水泥套疲劳失效； 4）那个 在循环荷载下，“锥滑”杆的永久沉降台阶为 与循环微运动的减少有关。本研究结果 将具有直接的临床意义，使外科医生能够制造更多 关于哪种茎类型最适合的明智决定 每个患者。成像技术也将促进发展 提高水泥罩寿命的阀杆设计。另外，裂纹 成像系统将用于干/骨水泥/股骨复合体的初步研究 死后恢复。预计该计划的成功实施 成像技术将有助于进一步的研究，包括分析 回收的茎/骨水泥/股骨复合体，这将有助于 NIAMS “种植体检索分析注册表的开发和使用”的研究目标 阐明失败的机制”。