Synergistic Effects of Ethnicity & Older Age in HIV/AIDS

种族的协同效应

• 批准号: 6546676
• 负责人: KAREN I WILSON
• 金额: $ 2.4万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6546676
• 关键词: AIDS; AIDS /HIV test; African American; HIV infections; adult human (21+); age difference; aging; caucasian American; clinical research; human subject; medically underserved population; mental health epidemiology; neuropsychological tests; neuropsychology; psychological aspect of aging; questionnaires; racial /ethnic difference

The proposed pilot study addresses two topic areas: 1) HIV/AIDS and Aging and 2) Racial/Ethnic Differences and Health Disparities. The primarily objective of the proposed study is to examine the synergistic effects of ethnicity and older age on neurocognitive functioning in HIV-infected adults. Ethnic disparities exist in the rate of HIV infection and mortality, relative to European Americans. As highly active anti-retroviral therapy permits HIV seropositive (HIV+) individuals to live longer, there is also a growing number of HIV+ individuals who are over the age of 50 and appear to be at increased risk for poor health outcome. Older African Americans may be at greatest risk for poor neurocognitive outcome because of the combined effects of age- and HIV- related cognitive decline as well as other factors that put them at increased risk for poor health (e.g., hypertension, diabetes, low socioeconomic status). Despite the high prevalence of HIV infection in African Americans and the growing number of older individuals infected with HIV, there has been minimal research investigating ethic differences in the neurocognitive sequelae of HIV infection especially in older HIV+ persons. The central aim of the proposed investigation is to examine the synergistic effects of ethnicity and older age on neurocognitive functioning in 1 HIV+ adults (50 African American; 50 European American); fifty percent of the participants will be over age 50. Another object is to identify those factors that differentially predict neurocognitive outcome in HIV+ African Americans and European Americans. Multivariate analyses of variance will be used to examine the effects of age and ethnicity, and the interactive effects of both on neurocognitive functions particularly affected by the aging process and HIV/AIDS. In addition to main effects for age and ethnicity, it is hypothesized that older African American participants will evidence particularly poor neurocognitive functioning. After accounting for age, education, and income, it is expected that acculturation and health risk factors that disproportionately affect African Americans (e.g., hypertension) will account for these ethnic disparities.

拟议的试点研究介绍了两个主题领域：1）艾滋病毒/艾滋病和衰老以及2）种族/种族差异和健康差异。 拟议研究的主要目的是检查种族和年龄较大的艾滋病毒感染成人神经认知功能的协同作用。与欧洲人相对于艾滋病毒感染和死亡率的率存在种族差异。由于高度活跃的抗逆转录病毒疗法允许HIV血清阳性（HIV+）个体的寿命更长，因此，越来越多的HIV+个体年龄超过50岁，似乎患有不良健康结果的风险。由于年龄和艾滋病毒相关的认知能力下降以及其他因素，使他们的健康风险增加（例如，高血压，糖尿病，糖尿病，低社会经济状况），年龄较大的神经认知结果的风险可能最大。尽管非洲裔美国人的HIV感染患病率很高，并且感染了HIV的老年人的数量越来越多，但仍有很少的研究研究了HIV感染的神经认知后遗症的道德差异，尤其是在老年HIV+患者中。拟议的调查的核心目的是检查1 HIV+成年人（50名非裔美国人； 50欧洲裔美国人）中种族和年龄对神经认知功能的协同作用； 50％的参与者将超过50岁。另一个目的是确定那些在艾滋病毒+非裔美国人和欧洲人中差异预测神经认知结果的因素。多元方差分析将用于检查年龄和种族的影响，以及两者对受衰老过程和HIV/AIDS尤其影响神经认知功能的互动效应。除了对年龄和种族的主要影响外，还假设非洲裔美国人的参与者将证明神经认知功能特别差。在考虑了年龄，教育和收入之后，预计对非裔美国人（例如高血压）不成比例的适应和健康风险因素将考虑这些种族差异。