Nursing's Impact on QOL Outcomes in Ovarian Cancer

护理对卵巢癌生活质量结果的影响

• 批准号: 6685819
• 负责人: RUTH MCCORKLE
• 金额: $ 54.5万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6685819
• 关键词: anxiety; clinical research; clinical trials; depression; female; health care cost /financing; health care service utilization; human subject; human therapy evaluation; longitudinal human study; nursing care evaluation; nursing care quality; nursing intervention; nursing research; nursing skill /technique; oncology nursing; ovary neoplasms; patient oriented research; psychiatric nursing; psychological stressor; quality of life; questionnaires; women's health

DESCRIPTION (provided by applicant): Women who develop ovarian cancer usually present with advanced disease at diagnosis and these women are at high risk for prolonged physical problems and sustained psychological distress over their illness trajectory. The specific aims of the study are to: 1) test the effects of a standardized nursing intervention protocol (SNIP) on quality of life (QOL) outcomes (anxiety, depressive symptoms, overall QOL, and uncertainty) for adult women newly diagnosed with ovarian cancer at 1, 3, and 6 months post-hospitalization as compared to adult women newly diagnosed with ovarian cancer who receive usual attention control care plus; 2) test the effects of SNIP on costs of care, including health services resource use; and 3) explore the differential effects of SNIP on patterns of symptom distress, number of symptoms, dimensions of QOL, number of complications, resource utilization including rehospitalizations, and survival. The design is a single blind, randomized clinical trial study to test the effects of a SNIP in 225 patients with ovarian cancer at 1,3, and 6 months post-hospitalization. The intervention is provided by an oncology advanced practice nurse working in consultation with a psychiatric consultation-liaison nurse over a 5-month period including post-surgical care and the initiation of chemotherapy. The effects of the intervention will be evaluated using self-report questionnaires administered at pre-treatment, 1, 3, and 6 months post-hospitalization. The intervention will be demonstrated to be cost effective when compared to costs incurred by patients who do not receive it. Cost data will be obtained from the Resource Information Management System at Yale-New Haven Hospital to measure directly required resources. Additional mediating or outcome variables include: patterns of symptom distress, dimensions of QOL, number of complications, resource utilization including rehospitalizations, and survival. Data analysis will include: mean difference analyses, individual difference analyses, and outcome analyses. The primary analysis will be a multivariate analysis of covariance with repeated measures.

描述（由申请人提供）：患卵巢癌的妇女通常在诊断时患有晚期疾病，并且这些女性面临长期身体问题的高风险，并且在其疾病轨迹上持续心理困扰。该研究的具体目的是：1）测试标准化护理干预方案（SIP）对生活质量（QOL）结果（焦虑，抑郁症状，整体QOL和不确定性）对新诊断为1、3和6个月的卵巢癌的成年妇女与新诊断后的胎盘疗法后6个月相比，与新诊断为成人诊断为卵巢癌后的卵巢癌的成年妇女对卵巢癌后的卵巢癌的影响。 2）测试剪切对护理成本的影响，包括卫生服务资源使用； 3）探索剪切对症状困扰，症状数量，质量QOL的数量，并发症的数量，资源利用（包括重新寄养和生存）的差异影响。该设计是一项单一的盲，随机临床试验研究，用于测试225例卵巢癌患者1,3和院后6个月患者的剪切作用。干预措施是由肿瘤学高级实践护士在与精神病学咨询的律师协商期间工作的5个月期间，包括手术后护理和化学疗法的启动。干预措施的影响将使用预处理后1、3和6个月时进行的自我报告调查表进行评估。与未收到的患者所产生的费用相比，该干预措施将被证明具有成本效益。成本数据将从耶鲁 - 新避风港医院的资源信息管理系统中获得，以衡量直接所需的资源。其他介导或结果变量包括：症状困扰的模式，QOL的尺寸，并发症的数量，资源利用，包括再培育质量和生存。数据分析将包括：平均差异分析，个体差异分析和结果分析。主要分析将是重复测量的协方差的多元分析。