Core--Methodology /Biostatistics

核心--方法论/生物统计学

• 批准号: 6649472
• 负责人: GEORGE A. KAPLAN
• 金额: $ 18.67万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6649472
• 关键词: biomedical facility; health; social psychology; social status; socioeconomics; statistical service /center; statistics /biometry; biomedical facility; health; social psychology; social status; socioeconomics; statistical service /center; statistics /biometry

DESCRIPTION (adapted from investigator's abstract): The Michigan Interdisciplinary Center on Social Inequalities, Mind, and Body (MICSIMB), will foster an interdisciplinary research program seeking to understand the interactions of psychosocial states (beliefs, attitudes, affective states, values, and social relationships), their determinants, stress, and pathophysiologic marker of stress, in the development of physical and mental disorders, in child development, and in aging. The investigators include a focus on socioeconomic and racial inequalities in health, and on lifecourse and community determinants in community-based samples of children and adults, men and women, and minorities. The projects represent novel, cost-effective, and interrelated investigations of: (1) the extent to which children's physical, emotional, and cognitive status reflect the influence of parental socioeconomic status, income trajectories economic stress, and community characteristics; (2) the role of glucocorticoid and serotonergic mechanisms in the associations between psychosocial states, SES, and excess risk for CVD; (3) the interrelations between a broad array of psychological attributes, their antecedents and health sequelae, and related biological markers of stress, within a multilevel representative community sample, utilizing state of the art assessment of community factors; (4) contributions of socioeconomic, biological, and psychosocial factors at different stages of the life course to a broad range of indicators of psychosocial well-being, cardiovascular risk factors, subclinical and diagnosed CVD in adulthood, using data reflecting over 50 years of assessments; and, (5) the impact of chronic economic stress, in situ, on health and function in a randomly selected cohort of poor women with young children who, as part of welfare reform, were moved from the AFDC roles in Michigan into a new "workfare" program. The development and utilization of new methodological and biostatistical tools, career development, and dissemination activities coupled with the above research program will help to further establish the MICSIMB as a major international center for the study of mind/body interactions and physical health and mental health, cardiovascular disease, aging, and child development. This will be accomplished by a team of 21 experienced researchers from nine disciplines who will come together in a symbiotic way on five research projects and efforts to expand the methodological and biostatistical tools available for such analyses.

描述（根据研究者的摘要改编）：密歇根州的社会不平等，思想和身体（MICSIMB）的跨学科中心（MICSIMB）将促进跨学科研究计划，旨在了解心理社会状态的相互作用和衰老。调查人员包括关注卫生中的社会经济和种族不平等，以及在社区和成人，男女，男女少数群体的基于社区的生活和社区决定因素上。这些项目代表了：（1）儿童的身体，情感和认知地位反映父母社会经济地位，收入轨迹经济压力和社区特征的影响的程度； （2）糖皮质激素和血清素能机制在心理社会状态，SES和CVD过多风险之间的关联中的作用； （3）在多层次代表性的社区样本中，通过对社区因素的最先进的评估，在多层次代表性的社区样本中，各种各样的心理属性，其先例和健康后遗症以及压力的相关生物标记之间的相互关系； （4）生活课程不同阶段的社会经济，生物学和社会心理因素的贡献对成年后的广泛的心理社会健康，心血管危险因素，亚临床和诊断的CVD的贡献，使用反映超过50年的评估的数据； （5）在随机选择的贫困妇女与幼儿的贫困妇女中，慢性经济压力对健康和功能的影响，这些妇女是福利改革的一部分，从密歇根州的AFDC角色转移到了一个新的“工作表”计划。新的方法论和生物统计工具，职业发展和传播活动的开发和利用以及上述研究计划将有助于进一步建立MICSIMB，成为主要国际思维/身体互动研究中心，身体健康和身体健康和心理健康，心血管疾病，衰老和儿童发展。这将由来自九个学科的21名经验丰富的研究人员组成的团队完成，他们将以共生的方式聚集在五个研究项目中，并努力扩展可用于此类分析的方法论和生物统计学工具。