CORE--RESEARCH ANIMAL FACILITY

核心——研究动物设施

• 批准号: 6605464
• 负责人: GORDON C HARD
• 金额: $ 24.29万
• 依托单位: INSTITUTE FOR CANCER PREVENTION
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6605464
• 关键词: Rodentias; animal breeding; animal care; animal colony; biomedical facility; laboratory rabbit

The Research Facility (RAF) of the AHFCC is a centralized unit located in the Naylor Dana Institute for Disease Prevention (NDI), representing the only resource for housing laboratory animals within the AHF. The objectives of the facility are to maintain research animals according to the principals of proper animal care and use, and to generate quality research data from the conduct of animal experiments. The RAF is considered a specialized facility because it not only provides routine animal care and maintenance through a team of trained animal care technicians, but also provides a special service for conducting the procedures involved in animal experimentation of behalf of investigators, carried out a team of skilled and qualified research biologists. The Chief of the Facility is Dr. Gordon C. Hard, who has a veterinary degree and certifications in laboratory animal science, toxicologic pathology, and general toxicology. The Attending Veterinarian is a consultant, Elihu Bond, D.V.M., who inspects the facility on a once-per-month basis, but is available for consultation at any time. The RAF occupies a net area of 12,310 square feet (14,200 gross square feet) designed around a conventional clean/dirty corridor system supporting a cage-wash area and a central bank of 14 animal holding rooms for rodents and rabbits only. Special purpose areas include two quarantine rooms: a semi-barrier room for immunodeficient mice, three treatment rooms with biocontainment or canopy hoods; metabolism, necropsy and clinical laboratories; food and bedding storage rooms, an diet-mixing kitchen. The facility has its own air-handling system which maintains on average a temperature of 72+/-8 degrees Fahrenheit and relative humidity of 50+/-10% providing 15-20 changes of fresh air per hour to the animal rooms. The facility is also fitted with an automated watering system. The RAF operates strictly according to regulatory guidelines. The animal care and use program is monitored by a 9-member Institutional Animal Care and Use Committee (IACUC) which ensures compliance with Public Health Service policy regarding welfare and human treatment of laboratory animals (Assurance no. A3293-01). The Committee includes the Attending Veterinarian, an external non-affiliated layperson, and scientific and non-scientific AHF staff. The facility has received full accreditation by the American Association for Accreditation of Laboratory Animal Care (AAALAC) since being established in 1976, and comes under triennial site-review to maintain this status. The facility is also inspected on a regular basis each year by both Federal and State governments. The AHF Biosafety and Biohazard Facility monitors the use of hazardous chemicals and other agents within the facility. NCI-funded new construction currently underway will provide office space for the RAF staff, as well as for relocation of a refurbished necropsy room.

AHFCC的研究机构（RAF）是位于Naylor Dana疾病预防研究所（NDI）的集中式单元，是AHF内住房实验室动物的唯一资源。该设施的目标是根据适当的动物护理和使用的原理维护研究动物，并从动物实验的进行中生成优质的研究数据。皇家空军被认为是专业设施，因为它不仅通过训练有素的动物护理技术人员提供常规的动物护理和维护，而且还提供了一项特殊的服务，以执行代表研究人员的动物实验的程序，还进行了一组熟练和合格的研究生物学家。该设施的负责人是Gordon C. Hard博士，他在实验室动物科学，毒理学病理学和一般毒理学方面拥有兽医学位和证书。参加兽医是D.V.M. Elihu Bond的顾问，他每月一次检查设施，但可以随时进行咨询。皇家空军的净面积为12,310平方英尺（14,200平方英尺），围绕一个传统的清洁/肮脏的走廊系统设计，该系统支撑着一个笼子洗净的面积和仅用于啮齿动物和兔子的14个动物饲养室的中央银行。特殊目的区域包括两个隔离室：一个半锁定室，用于免疫缺陷小鼠，三个带有生物内在的治疗室或冠层罩；代谢，尸检和临床实验室；食物和床上用品储藏室，饮食中的厨房。该设施具有自己的空气处理系统，平均温度为72 +/-华氏8度，相对湿度为50 +/- 10％，每小时为动物室提供15-20个新鲜空气的变化。该设施还配备了自动浇水系统。皇家空军根据监管指南严格运行。动物护理和使用计划由由​​9人组成的机构动物护理和使用委员会（IACUC）监视，该委员会确保遵守有关实验动物福利和人类治疗的公共卫生服务政策（AssuranceNo。A3293-01）。该委员会包括参加兽医，外部非附属外行以及科学和非科学的AHF员工。自1976年成立以来，该设施已获得美国实验室动物护理认证协会（AAAALAC）的全面认证，并受到三年期地点审查以保持这种地位。联邦和州政府每年还会定期检查该设施。 AHF Biosafety和Biohazard设施监视了该设施内有害化学物质和其他代理的使用。当前正在进行的NCI资助的新建筑将为RAF员工提供办公空间，并为重新固定的死灵室提供搬迁。