CORE--RESEARCH ANIMAL FACILITY

核心——研究动物设施

• 批准号: 6101846
• 负责人: GORDON C HARD
• 金额: $ 26.2万
• 依托单位: INSTITUTE FOR CANCER PREVENTION
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-18 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6101846
• 关键词: animal breeding; animal care; animal colony; biomedical facility; laboratory mouse; laboratory rabbit; laboratory rat

The Research Animal Facility (RAF) of the AHFCC is a centralized unit located in the Naylor Dana Institute for Disease Prevention (NDI), representing the only resource for housing laboratory animals within the AHF. The objectives of the facility are to maintain research animals according to the principles of proper animal care and use, and to generate quality research data from the conduct of animal experiments. The facility not only provides routine animal care and maintenance through a team of trained animal care technicians, but also provides a specialized service for conducting the procedures involved in animal experimentation carried out by a team of skilled, qualified research biologists. The RAF occupies a net of 10,030 square feet (14,200 gross square feet) designed around a conventional clean, dirty corridor system supporting a cage-wash area and a central bank of 14 animal holding rooms for rodents and rabbits only. Special purpose areas include two quarantine rooms; a semi-barrier room for immunodeficient mice; three treatment rooms when biocontainment or canopy hoods; metabolism, necropsy and clinical laboratories, food and bedding storage rooms; and diet mixing kitchen. The facility has its own air-handling system which maintains on average a temperature of 72 +/-8 degrees Fahrenheit and relative humidity of 50 +/-10% providing 15-20 changes of fresh air per hour to the animal rooms. The facility is also fitted with an automated watering system. The RAF operatives strictly according to regulatory guidelines. The animal care and use program is monitored by a 9-member Institutional Animal Care and Use Committee(IACUC) which ensures compliance with Public Health Service policy regarding welfare and humane treatment of laboratory animals. The Committee includes the Attending Veterinarian, an external non-affiliated lay-person, and scientific and non-scientific AHF staff. The facility has received full accreditation by the American Association for Accreditation of Laboratory Animal Care (AAALAC) since being established in 1976, and come under triennial site-review to maintain this status. The facility is also inspected on a regular basis each year by both Federal and State governments and periodically by officers of the Food and Drug Administration. The AHF Biosafety and Biohazard Facility monitors the use of hazardous chemicals and other agents within the facility.

AHFCC的研究动物设施（RAF）是一个集中式单元 位于Naylor Dana疾病预防研究所（NDI）， 代表唯一用于住房实验室动物的资源 AHF。该设施的目标是维持研究动物 根据适当的动物护理和使用的原则，并产生 来自动物实验的行为的质量研究数据。设施 不仅通过一个团队提供常规的动物护理和维护 训练有素的动物护理技术人员，但也提供专业服务 用于进行动物实验涉及的程序 由一支熟练的，合格的研究生物学家团队。皇家空军占据 围绕一个净面积10,030平方英尺（14,200平方英尺） 传统的干净，肮脏的走廊系统，支持笼子洗净区域 中央银行组成的14只动物藏有啮齿动物和兔子的房间。 特殊目的区域包括两个隔离房间；一个半级舞厅 用于免疫缺陷的小鼠；生物内在或 树冠罩；代谢，尸检和临床实验室，食物和 床上用品储藏室；和饮食混合厨房。该设施有自己的 平均温度为72 +/- 8的空气处理系统 华氏度和相对湿度为50 +/- 10％，提供15-20 动物室每小时新鲜空气的变化。设施也是 安装有自动浇水系统。皇家空军的特工严格 根据监管指南。动物护理和使用程序是 由由9人组成的机构动物护理和使用委员会（IACUC）监视 这确保遵守有关公共卫生服务政策 实验动物的福利和人道处理。委员会包括 参加兽医，外部非附属的外行人， 科学和非科学的AHF员工。该设施已满 美国实验室认证协会的认证 自1976年成立以来的动物护理（AAAALAC），并受到 三年展的站点审查以维持此状态。设施也是 每年都会定期检查联邦和州 政府并定期由食品和毒品官员 行政。 AHF BioSafety和Biohazard设施监视使用 设施内的危险化学品和其他代理的构造。