PLATELET PRODUCTION & DESTRUCTION

血小板生产

• 批准号: 6565708
• 负责人: LAURENCE A HARKER
• 金额: $ 29.31万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6565708
• 关键词: bone marrow disorder; cellular pathology; chromosome aberrations; clinical research; flow cytometry; hematopoiesis; human subject; megakaryocytes; platelets

In this study, the analysis of marrow megakaryocytes (using fluorescence-activated flow cytometry) will be combined with platelet flow cytometric and platelet kinetic measurements to characterize platelet production and destruction in patients with megakaryocytopoiesis. We will test the hypothesis that alteration in megakaryocytic ploidy constitutes important compensatory mechanisms responding to changes in peripheral platelet demand, and that the resultant physiologic changes in ploidy and size are subject to pathologic aberrations.

在本研究中，骨髓巨核细胞分析（使用荧光激活流式细胞术）将与血小板流式细胞术和血小板动力学测量相结合，以表征巨核细胞生成患者的血小板产生和破坏。 我们将检验以下假设：巨核细胞倍性的改变构成了响应外周血小板需求变化的重要补偿机制，并且由此产生的倍性和大小的生理变化受到病理畸变的影响。