Core--Neuropathology

核心--神经病理学

• 批准号: 6578727
• 负责人: JUAN TRONCOSO
• 金额: $ 15.83万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6578727
• 关键词: Alzheimer's disease; aging; animal tissue; biomedical facility; brain disorder diagnosis; genetically modified animals; genotype; histopathology; human tissue; laboratory mouse; neural degeneration; patient /disease registry; postmortem; tissue /cell preparation; tissue resource /registry; training

DESCRIPTION: (Adapted from the application) The Neuropathology Core (Core C) arranges and conducts autopsies, performs neuropathological evaluations of human subjects (Core B, Project 4), and assists in the assessment of transgenic (Tg) animal models of AD (Projects 1-3). To support research that requires brains from humans, Core C operates the Brain Resource Center (BRC), a repository of fixed/frozen autopsy tissues. The faculty of Core C plays a critical role in training basic scientists and physicians in the pathology of aging and neurodegenerative diseases, consults with outside pathologists on cases of dementia, and does genotyping relevant to AD. The Core C prospective autopsy program is unique because of the large proportion of control subjects from the Baltimore Longitudinal Study of Aging (BLSA) (Core B). During the next five years, it is projected that a total of 113 autopsies, 71 of which will be longitudinally characterized subjects from the BLSA. Many of these individuals will have had neuroimaging studies as part of a parallel NIA study. Tissues from these subjects, as well as from other cases of AD, will be accessed to the BRC and will continue to be made available for research, not only within the ADRC, but to the scientific community at large. Core C will support morphological studies of Tg mice that recapitulate several of the pathological features of AD (Projects 1- 3). These lines of behaviorally characterized congenic Mo/HuAPPswe Tg mice recapitulate several of the pathological features of AD (Projects 1-3). Many of these analyses will require quantitative morphometry and, therefore, support will require the assistance of the histology laboratory and stereology unit. Through these multiple activities, Core C acts to facilitate and coordinate the evaluations of both clinical and experimental material in Projects 1-4, thereby greatly enhancing the diagnostic and research capabilities of our ADRC.

描述：（从应用程序改编） 神经病理学核心（核心C）安排和进行尸检，执行 人类受试者的神经病理学评估（核心B，项目4）和 协助评估AD的转基因（TG）动物模型（项目 1-3）。为了支持需要人类大脑的研究，核心C运行 大脑资源中心（BRC），固定/冷冻尸检组织的存储库。 核心C的教师在培训基本科学家和 衰老和神经退行性疾病病理学的医生，咨询 与外部病理学家有关痴呆病例，并具有相关的基因分型 广告。核心C前瞻性尸检程序是独一无二的 巴尔的摩纵向研究的控制受试者的比例 （blsa）（核心B）。在接下来的五年中，预计总共 113个尸检，其中71个将是纵向表征的主题 blsa。这些人中的许多人都将进行神经影像学作为一部分 一项平行的NIA研究。这些受试者的组织以及其他 AD案例将访问BRC，并将继续进行 不仅可以在ADRC内部，而且可用于研究 整个社区。核心C将支持TG小鼠的形态学研究 概括了AD的几种病理特征（项目1-3）。这些 行为表征的线条含量的先天性MO/HUAPPSWE TG小鼠概括 AD的几个病理特征（项目1-3）。其中许多 分析将需要定量形态计量学，因此支持将 需要组织学实验室和立体学部门的协助。 通过这些多种活动，核心C采取行动促进和协调 在项目1-4中对临床和实验材料的评估， 从而大大增强了我们的诊断和研究能力 ADRC。