SIGNALING THROUGH THE CYTOSKELETAL PROTEIN, PAXILLIN

通过细胞骨架蛋白 PAXILLIN 发出信号

• 批准号: 6376537
• 负责人: SHEILA M. THOMAS
• 金额: $ 26.38万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-15 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6376537
• 关键词: actin binding protein; biological signal transduction; cell line; cell transformation; developmental genetics; genetically modified animals; histology; integrins; laboratory mouse; paxillin; protein kinase; protein sequence; protein structure function

DESCRIPTION: Dr. Thomas will build on her exciting preparation of pax-/- mice to investigate the role of this intriguing adapter protein in development, interactions of cells with the extracellular matrix, and as a target of transforming oncogenes such as src or abl.

描述：Thomas 博士将以她令人兴奋的 pax-/- 准备工作为基础 小鼠研究这种有趣的接头蛋白在 发育、细胞与细胞外基质的相互作用以及作为 转化癌基因的靶标，例如 src 或 abl。

项目成果

Cortactin regulates cell migration through activation of N-WASP.

Cortactin 通过激活 N-WASP 来调节细胞迁移。

• 发表时间: 2005-01-01
• 作者: Kowalski, Jennifer R;Egile, Coumaran;Gil, Susana;Snapper, Scott B;Li, Rong;Thomas, Sheila M
• 通讯作者: Thomas, Sheila M

Regulation of Rho and Rac signaling to the actin cytoskeleton by paxillin during Drosophila development.

果蝇发育过程中桩蛋白对肌动蛋白细胞骨架的 Rho 和 Rac 信号传导的调节。

• 发表时间: 2005-02
• 作者: Chen, Guang;Turano, Brian;Ruest, Paul J;Hagel, Margit;Settleman, Jeffrey;Thomas, Sheila M
• 通讯作者: Thomas, Sheila M

An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival.

Shp2/SFK/Ras/Erk 信号通路控制滋养层干细胞的存活。

• DOI: 10.1016/j.devcel.2006.01.002
• 发表时间: 2006-03-01
• 期刊: Developmental cell
• 影响因子: 11.8
• 作者: Wentian Yang;L. Klaman;Binbin Chen;T. Araki;H. Harada;Sheila M. Thomas;E. L. George;B. Neel
• 通讯作者: B. Neel