Novel Detector for Small Animal SPECT Imaging

用于小动物 SPECT 成像的新型探测器

• 批准号: 6479290
• 负责人: GERALD ENTINE
• 金额: $ 10.65万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-14 至 2004-05-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6479290
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; cesium; electrodes; image enhancement; iodine; miniature biomedical equipment; nuclear medicine; radiation detector; radionuclides; single photon emission computed tomography; thallium

Nuclear medicine techniques (such as SPECT) have the potential to become powerful new tools in imaging biological processes in small laboratory animals. With the every increasing number of human disease models, particularly in the smaller animals such as mice and rats, the potential of high resolution nuclear medicine nuclear medicine technologies to contribute unique information is becoming apparent to many researchers. Clinical radionuclide systems are not suitable for imaging small animals because their spatial resolution is not adequate. This makes commercial SPECT systems are not suitable for imaging small animals because their spatial resolution is not adequate. This makes commercial SPECT systems unsuitable for resolving millimeter- sized structures in mice. Hence, dedicated, low cost instruments are required for conducting small animal studies with higher spatial resolution than what is current achieved with clinical SPECT scanners. The goal of the proposed research is to investigate a novel position sensitive detector concept for small animal SPECT imaging. The proposed approach is expected to provide high spatial resolution, and the system is expected to be simpler and lower in cost as compared to other approaches being investigated. Nuclear medicine including positron emission tomography, and single photon emission computed tomography, radiology, non-destructive testing, materials research, X-ray diffraction, nuclear and high energy physics research, astronomy, and geological exploration.

核医学技术（例如SPECT）有可能成为小型实验室动物的生物学过程的强大新工具。随着每一个越来越多的人类疾病模型，尤其是在小鼠和大鼠等较小的动物中，高分辨率核医学核医学技术的潜力对于许多研究人员来说是显而易见的。临床放射性核素系统不适合成像小动物，因为它们的空间分辨率不足。这使得商业SPECT系统不适合成像小动物，因为它们的空间分辨率不足。这使得商业SPECT系统不适合在小鼠中解决毫米大小的结构。因此，与临床SPECT扫描仪相比，进行具有更高空间分辨率的小动物研究所需的专用，低成本工具是需要的。拟议的研究的目的是研究用于小动物SPECT成像的新型位置敏感探测器概念。预计所提出的方法将提供高空间分辨率，并且与正在研究的其他方法相比，该系统的成本将更简单和较低。核医学包括正电子发射断层扫描以及单光子发射计算机断层扫描，放射学，非破坏性测试，材料研究，X射线衍射，核和高能量物理学研究，天文学和地质探索。