Development of an Anti-Diabetes Botanical Nutraceutical

抗糖尿病植物保健品的开发

• 批准号: 6586951
• 负责人: NEBOJSA ILIC
• 金额: $ 9.98万
• 依托单位: PHYTOMEDICS, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-20 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586951
• 关键词: alternative medicine; angiosperms; biotherapeutic agent; blood glucose; dietary supplements; drug design /synthesis /production; drug discovery /isolation; drug screening /evaluation; hypoglycemic agents; insulin dependent diabetes mellitus; insulin sensitivity /resistance; laboratory rat; nutrition related tag; plant extracts

DESCRIPTION (provided by applicant): This is a revised proposal for the pre-clinical development of PMI-5011, a standardized botanical extract, developed by Phytomedics Inc. and Rutgers University. PMI-5011 effectively lowers blood glucose in insulin deficient and insulin resistant animals, does not cause hypoglycemia, and is safe and non-toxic. All data suggest that PMI-5011 is an efficacious nutritional supplement for those suffering from diabetes or prediabetic conditions. Preliminary results demonstrate that PMI-5011 specifically affects hepatic gene expression in diabetic rats and promotes insulin mediated glucose uptake by muscle tissues as potential means of normalizing glycemia. Phytomedics will use the SBIR funds to complete the necessary pre-clinical investigation of PMI-5011 and to produce a sufficient supply of the standardized and optimized PMI-5011 material for the remaining preclinical and clinical testing. Phytomedics will also confirm the identity of the active ingredients of PMI-5011 and determine optimal hydroponic greenhouse methods for the source plant cultivation. Phytomedics will conduct limited clinical trials of PMI-5011 in Phase 2 of this proposal. Phase 3 of this proposal will involve the full-scale commercialization of PMI-5011 with a commercial partner, using PMI-5011 exclusively supplied by Phytomedics.

描述（由申请人提供）：这是针对 PMI-5011 临床前开发的修订提案，PMI-5011 是一种标准化植物提取物，由 Phytomedics Inc. 和罗格斯大学开发。 PMI-5011能有效降低胰岛素缺乏和胰岛素抵抗动物的血糖，不会引起低血糖，安全无毒。所有数据表明 PMI-5011 对于患有糖尿病或糖尿病前期疾病的人来说是一种有效的营养补充剂。初步结果表明，PMI-5011 特异性影响糖尿病大鼠的肝脏基因表达，并促进肌肉组织对胰岛素介导的葡萄糖摄取，作为血糖正常化的潜在手段。 Phytomedics 将利用 SBIR 资金完成 PMI-5011 必要的临床前研究，并为剩余的临床前和临床测试生产充足的标准化和优化的 PMI-5011 材料。 Phytomedics 还将确认 PMI-5011 活性成分的身份，并确定源植物栽培的最佳水培温室方法。 Phytomedics 将在该提案的第二阶段进行 PMI-5011 的有限临床试验。该提案的第 3 阶段将涉及与商业合作伙伴一起使用 Phytomedics 独家供应的 PMI-5011 将 PMI-5011 全面商业化。