Diabetic Foot Ulcer Healing by Load Relieving Dressing

通过减轻负荷敷料治愈糖尿病足溃疡

• 批准号: 6549804
• 负责人: JOSEPH L LOOMIS
• 金额: $ 19.95万
• 依托单位: DIAPEDIA, LLC
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2003-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6549804
• 关键词: biomaterial development /preparation; biomaterial evaluation; clinical biomedical equipment; clinical research; decubitus ulcer; diabetes mellitus; foot; human subject; mechanical pressure; wound healing

DESCRIPTION (provided by applicant): In the US at least 200,000 diabetes related foot ulcers per year affect patients and the majority of the more than 80,000 lower extremity amputations performed in diabetic patients per year are preceded by a foot ulcer. Usual care ulcer healing rates are typically only about 30% in 20 weeks, yet a total contact cast (TCC) can heal > 90% of ulcers in 8 weeks on average. However, acceptance of the TCC by providers is poor for a number of reasons and thus efficacious alternatives must be found. The present proposal seeks to demonstrate the feasibility of a prototype Load Relieving Dressing (LRD) using quantitative methods to measure plantar pressures on the foot in patients with deformities that typically cause plantar ulcers, after the mechanical threshold for healing has been defined in ulcer patients. Once feasibility of the dressing concept has been demonstrated we will follow up with a phase II proposal in which finite element modeling will be used to refine the LRD. This product not only has commercial potential, but also offers the possibility of putting a tool into the hands of providers which could heal many ulcers faster than is usual at present and could therefore prevent many lower extremity amputations.

描述（由申请人提供）：在美国，每年至少有200,000个相关的糖尿病会影响患者，并且在每年在糖尿病患者中进行的80,000多个下肢截肢术中的大多数都伴有步进溃疡。通常在20周内通常只有30％的护理溃疡愈合率，但是总的接触式铸件（TCC）平均可以在8周内治愈90％的溃疡。但是，由于多种原因，提供者接受TCC的接受是不良的，因此必须找到有效的替代方案。本提案旨在使用定量方法来证明原型负荷减轻敷料（LRD）的可行性，以测量通常导致足底溃疡的畸形患者的足底压力，在溃疡患者的机械愈合阈值之后。一旦证明了敷料概念的可行性，我们将跟进II期提案，其中有限元建模将用于完善LRD。该产品不仅具有商业潜力，而且还提供了将工具放在提供商手中的可能性，这些工具可以比目前通常更快地治愈许多溃疡，因此可以防止许多下肢截肢。