ASCB Conf:Nontraditional Functions of Ubiquitin and UbLs

ASCB Conf：泛素和 UbL 的非传统功能

• 批准号: 6562513
• 负责人: Cecile M. Pickart
• 金额: $ 2万
• 依托单位: AMERICAN SOCIETY FOR CELL BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-12 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6562513
• 关键词: meeting /conference /symposium; travel; ubiquitin

DESCRIPTION (provided by applicant): The conference "Nontraditional Functions of Ubiquitin and Ubiquitin-Like Proteins (UbLs)" will be held from August 12 through August 14, 2002, at the Conference Center of Colorado College in Colorado Springs, Colorado. This meeting is sponsored and partially funded by the American Society for Cell Biology (ASCB). This conference is the only international meeting this year that focuses on noncanonical functions of Ub and is open to a significant number of young scientists who are not established members of the ubiquitin field. The purpose of this conference is to foster interactions between scientists from diverse biological backgrounds who are working on non-proteasome-dependent roles of ubiquitin and UbLs. In this application we request partial funding for the 2002 conference. Increasing evidence suggests that ubiquitin and UbLs regulate cell functions by mechanisms that are independent of proteasome-mediated degradation. The conference will focus on these expanding, newly-discovered functions, with little coverage of proteasomal proteolysis. Some of the most exciting current work in the ubiquitin field is in the area of monoubiquitination, a modification that seldom targets substrates to proteasomes. The emerging roles of monoubiquitination and UbLs squarely place these modifiers within processes of central interest to cell biologists, including the endocytosis of growth factor receptors, protein transport, intracellular signaling, the inflammatory response, viral assembly, development, gene regulation, and DNA repair. Defects in the monoubiquitination of specific proteins are directly linked to an inherited form of severe hypertension and several forms of cancer. Ubiquitin-like proteins also modify proteins, such as the p53tumor suppressor and its dedicated ubiquitin ligase, Mdm2, that play crucial roles in cancer prevention. The conference will convene scientists from this broad range of research areas. The aforementioned topics are among those to be addressed in the five scientific sessions of the 2002 ASCB Summer Conference. These sessions will consist of a mixture of invited talks and presentations to be selected based on submitted abstracts. The latter speakers will be chosen with special attention to younger investigators and exciting recent developments. There will also be a poster session. The format of the Conference, and its small size, are designed to foster interactions among the 200 participants.

描述（由申请人提供）：会议“泛素和泛素样蛋白（UBL）的非传统功能”将于2002年8月12日至2002年8月14日在科罗拉多州科罗拉多斯普林斯的科罗拉多斯普林斯会议中心举行。这次会议由美国细胞生物学学会（ASCB）赞助并部分资助。这次会议是今年唯一一次关注UB非规范功能的国际会议，并向许多未建立泛素领域成员的年轻科学家开放。这次会议的目的是促进来自从事泛素和UBL非依赖性角色的不同生物学背景的科学家之间的互动。在此应用程序中，我们要求为2002会议的部分资金提供部分资金。越来越多的证据表明，泛素和UBL通过独立于蛋白酶体介导的降解的机制来调节细胞功能。该会议将重点放在这些不断扩展的新发现的功能上，几乎没有蛋白酶体蛋白水解范围。泛素场中最令人兴奋的当前工作是单泛素化的领域，这种修饰很少将底物靶向蛋白酶体。单样泛素化和UBL的新兴作用将这些修饰符正式置于细胞生物学家的中心兴趣过程中，包括生长因子受体的内吞作用，蛋白质转运，细胞内信号传导，炎症反应，病毒组装，病毒组装，发育，基因调控和DNA修复。特定蛋白质单泛素化的缺陷直接与严重高血压的遗传形式和几种形式的癌症有关。泛素样蛋白还会修饰蛋白质，例如p53Tumor抑制剂及其专用的泛素连接酶MDM2，它们在预防癌症中起着至关重要的作用。会议将召集来自这个广泛研究领域的科学家。上述主题是在2002年ASCB夏季会议的五个科学会议上解决的主题。这些会议将包括根据提交的摘要选择的邀请会谈和演讲的混合。后者的演讲者将特别注意年轻的研究人员和令人兴奋的最近发展。还将有一个海报会议。会议的格式及其规模较小，旨在促进200名参与者之间的互动。