Endotoxin, Obesity, and Asthma in NYC Head Start

纽约市的内毒素、肥胖和哮喘

• 批准号: 6548349
• 负责人: JUDITH S JACOBSON
• 金额: $ 98.86万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6548349
• 关键词: air pollution; airborne allergen; asthma; blood chemistry; body physical activity; bronchomotion; clinical research; developmental immunology; disease /disorder proneness /risk; endotoxins; human subject; middle childhood (6-11); nitrogen oxides; obesity; pollution related respiratory disorder; preschool child (1-5); respiratory disorder epidemiology; respiratory function; respiratory hypersensitivity

DESCRIPTION (provided by applicant): In the United States, overall asthma prevalence has increased by 60 percent since 1980, and the increase in asthma hospitalizations is greatest among preschool-age children of Hispanic and African descent living in low-income urban areas. Indoor aeroallergens and irritants are known to trigger asthma exacerbations, but in recent years, preliminary evidence has implicated additional factors associated with modem urban environments and lifestyles as contributing to risk for asthma. These risk factors are obesity and physical inactivity, which are similar to asthma in descriptive epidemiology and appear to heighten bronchial reactivity, and lack of early exposure to infectious agents and/or substances, such as endotoxin, that appear to promote the development of the immune system. Nitrogen dioxide (NO2), an irritant, is also suspect because it enhances susceptibility to some infectious agents. We propose to study the association of these risk factors with the prevalence, persistence, and incidence of asthma or asthma-like conditions over a three-year period in a cohort of children entering Head Start programs in high-risk neighborhoods in New York City, including those exposed to airborne particulate matter from Ground Zero. Our study will begin with a telephone survey of asthma symptoms and risk factors among parents of 2000 3-4-year-olds entering Head Start programs in neighborhoods with >20 asthma hospitalizations per 1000 preschool-age children per year. From the respondents, we will recruit a cohort of 1000 for 2 annual follow-up telephone interviews; of these 500 will also receive 3 annual home visits to measure endotoxin, aeroallergens (cat, mouse, and cockroach), and NO2 in the home, and height, weight, physical activity, and pulmonary function in the child. Blood specimens collected annually from the child and once from each parent will be analyzed for antioxidant levels, cotinine, and total and specific IgE. We will also conduct environmental sampling within the Head Start centers twice a year. Our goal is to identify risk factors that interventions can target to lighten the burden of asthma on school-age children.

描述（由申请人提供）：在美国，自 1980 年以来，哮喘总体患病率增加了 60%，而居住在低收入城市地区的西班牙裔和非洲裔学龄前儿童的哮喘住院人数增幅最大。众所周知，室内空气过敏原和刺激物会引发哮喘发作，但近年来，初步证据表明与现代城市环境和生活方式相关的其他因素也会导致哮喘风险。这些危险因素是肥胖和缺乏身体活动，这在描述性流行病学中与哮喘相似，似乎会增强支气管反应性，以及缺乏早期接触感染因子和/或物质，如内毒素，这些因子和/或物质似乎会促进免疫系统的发展。系统。二氧化氮 (NO2) 是一种刺激物，也值得怀疑，因为它会增加对某些传染源的易感性。我们建议在三年的时间内，在纽约市高风险社区参加启蒙计划的一组儿童中，研究这些风险因素与哮喘或哮喘样疾病的患病率、持续性和发病率之间的关系，包括那些暴露于归零地空气颗粒物的人。 我们的研究首先对 2000 名 3-4 岁儿童的父母进行哮喘症状和危险因素的电话调查，这些儿童参加了 Head Start 计划，这些儿童每年每 1000 名学龄前儿童中有超过 20 人因哮喘住院。我们将从受访者中招募 1000 人进行每年 2 次的后续电话访谈；这 500 名儿童中还将接受每年 3 次家访，以测量家中的内毒素、空气过敏原（猫、老鼠和蟑螂）和二氧化氮，以及儿童的身高、体重、体力活动和肺功能。每年从孩子身上采集的血液样本以及从父母双方采集的血液样本将进行抗氧化剂水平、可替宁以及总 IgE 和特异性 IgE 的分析。我们还将每年在启蒙中心内进行两次环境采样。我们的目标是确定干预措施的风险因素，以减轻学龄儿童的哮喘负担。