Aeroallergens, Air Pollution and Respiratory Health in the Chickasaw Nation A1

契卡索族的空气过敏原、空气污染和呼吸系统健康 A1

• 批准号: 10239486
• 负责人: Amanda E Janitz
• 金额: $ 23.7万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10239486
• 关键词: Accounting; Address; Adult; Age; Air; Air Pollutants; Air Pollution; American Indians; Area; Asthma; Awareness; Biological; Chickasaw Nation; Chronic; Clinic Visits; Clinical; Colorado; Communities; Data; Devices; Diagnosis; Direct Costs; Educational Intervention; Environmental Risk Factor; Etiology; Exposure to; Facilities and Administrative Costs; Frequencies; Geographic Locations; Global Positioning System; Goals; Health; Health Promotion; High Prevalence; Hour; Household; Individual; Interview; Location; Lung diseases; Maps; Measures; Meteorology; Metered Dose Inhaler Device; Methods; Modeling; Monitor; Morbidity - disease rate; Neighborhoods; Nurses; Oklahoma; Outcome; Ozone; Participant; Particulate Matter; Patient Recruitments; Patients; Pollen; Population; Prevalence; Public Health; Reporting; Research; Research Personnel; Research Project Grants; Risk Factors; Role; Rural Population; Sampling; Series; Smoking; Societies; Source; Technology; Time; Tribes; United States Public Health Service; Universities; Urban Population; Visit; Work; airborne allergen; anthropogenesis; asthma exacerbation; asthma inhaler; base; college; cost; improved; land use; member; metropolitan; mortality; novel; pollutant; prevent; recruit; respiratory health; respiratory morbidity; rural Americans; tribal health; weather patterns

Project Summary/Abstract American Indians are disproportionately impacted by asthma. The Chickasaw Nation, located in southcentral Oklahoma, reports clinic visits for asthma as one of the top diagnoses, accounting for 7% of patients at Chickasaw Nation Department of Health. Due to the high patient burden for asthma in Chickasaw Nation, the Tribe has identified a need to better understand risk factors for asthma-related morbidity. The long-term goal of this research is to understand the impact of aeroallergens and anthropogenic air pollution on asthma morbidity in Chickasaw Nation and to investigate more efficient ways to monitor, control, and ultimately prevent asthma morbidity among this highly-susceptible population. The Chickasaw Nation provides clinical and public health services for the majority of American Indians residing within their jurisdictional area in southcentral Oklahoma; thus, improving the health of the Tribe promotes the health of the overall community. This study provides a unique opportunity to evaluate the effect of ambient aeroallergens (pollen) and anthropogenic air pollution (particulate matter, ozone) on asthma-related morbidity using a novel device to measure the time and location of metered-dose inhaler (MDI) use in a rural, American Indian population. This in-depth study will allow researchers and the Tribe to: 1) evaluate the association of spatially- and temporally-resolved aeroallergens and anthropogenic pollutants with Global Positioning System (GPS)-enabled MDIs among Chickasaw Nation community members with asthma, and 2) compare the participants' perceived individual and neighborhood asthma triggers to the spatial and temporal data collected through the MDIs using sketch maps and interviews. We are partnering with Propeller Health to use GPS-enabled MDIs to measure asthma exacerbations, which will allow us to collect the exact time and location of the MDI actuation. We will evaluate whether the measured exposures are associated with MDI actuation using a time-series model accounting for lag times up to one week. At the end of the study, the participants will develop sketch maps that describe the perceived geographic locations of their asthma triggers. Our central hypothesis is that aeroallergen and air pollution levels in Chickasaw Nation interact synergistically to increase the prevalence of asthma-related morbidity. Longitudinal data on aeroallergens and asthma are sparse in American Indian populations and awareness of triggers will help improve asthma management in Chickasaw Nation. This study provides a unique opportunity to evaluate the effect of aeroallergens and anthropogenic air pollution on asthma morbidity using a novel device to measure the time, frequency, and location of MDI use in this population.

项目概要/摘要 美洲印第安人受哮喘影响尤为严重。契卡索族 (Chickasaw Nation)，位于中南部 俄克拉荷马州报告称，哮喘门诊就诊是最常见的诊断之一，占该州患者的 7% 契卡索国家卫生部。由于契卡索族的哮喘患者负担较高， Tribe 认为需要更好地了解哮喘相关发病的危险因素。长期目标是 这项研究旨在了解空气过敏原和人为空气污染对哮喘发病率的影响 契卡索族并研究更有效的方法来监测、控制并最终预防哮喘 这一高度易感人群的发病率。 Chickasaw Nation 提供临床和公共卫生服务 为居住在俄克拉荷马州中南部管辖范围内的大多数美洲印第安人提供服务； 因此，改善部落的健康可以促进整个社区的健康。这项研究提供了 评估环境空气过敏原（花粉）和人为空气污染影响的独特机会 （颗粒物、臭氧）使用新型设备测量时间和位置来降低哮喘相关发病率 美国印第安人农村人口使用计量吸入器 (MDI) 的情况。这项深入的研究将使 研究人员和部落：1）评估空间和时间分辨的空气过敏原的关联 奇卡索族人为污染物与全球定位系统 (GPS) 启用的 MDI 患有哮喘的社区成员，2) 比较参与者对个人和社区的感知 哮喘触发通过 MDI 使用草图和访谈收集的空间和时间数据。 我们正在与 Propeller Health 合作，使用支持 GPS 的 MDI 来测量哮喘恶化情况，这将 允许我们收集 MDI 启动的准确时间和位置。我们将评估测量是否 使用时间序列模型将暴露与 MDI 驱动相关联，该模型考虑了长达一周的滞后时间。 在研究结束时，参与者将绘制描述感知地理的草图 哮喘诱发因素的位置。我们的中心假设是奇卡索的空气过敏原和空气污染水平 国家间协同相互作用，增加了哮喘相关发病率。纵向数据 空气过敏原和哮喘在美洲印第安人中很少见，对诱因的认识将有助于改善 契卡索族的哮喘管理。这项研究提供了一个评估效果的独特机会 使用新型设备测量时间来研究空气过敏原和人为空气污染对哮喘发病率的影响， 该人群使用 MDI 的频率和地点。