CORE--PHARMACOLOGY AND ANALYTIC CENTER FACILITY

核心——药理学和分析中心设施

• 批准号: 6352710
• 负责人: ROBERT A. NEWMAN
• 金额: $ 25.41万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-18 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6352710
• 关键词: analytical chemistry; biomedical facility; gas chromatography mass spectrometry; high performance liquid chromatography; mass spectrometry; neoplasm /cancer pharmacology; nuclear magnetic resonance spectroscopy; pharmacokinetics; radiochemistry

The overall goal of the Pharmacology and Analytical Center Facility is to provide the broad base of sophistical analytical equipment and expertise in pharmacology and medicinal chemistry required for preclinical and clinical investigations of anti-cancer drugs and related therapies. This goal will be accomplished by focusing on three aims. First, the Pharmacology and Analytical Center Facility will enable expanded analytical support for basic and clinical scientists at The University of Texas M.D. Anderson Cancer Center. This support will include access to instruments for nuclear magnetic resonance (NMR), liquid chromatography (LC)/mass spectrometry (MS), gas chromatography (GC), GC/MS, and high- performance liquid chromatography (HPLC). Support will also include assistance with the verification of structural identify, purification, and determination of stability of drugs and drug metabolites, as well as assistance with developing assays, solving proof-of-identity problems, and developing validation procedures. Second, scientists running the Pharmacology and Analytical Center Facility will provide a resource for investigators seeking pharmacokinetic and pharmacodynamic information on specific compounds and knowledge off how to best use such information for optimal protocol design, dose adjustments to increase efficacy or decrease toxicity, and similar clinical problems. Finally, the Pharmacology and Analytical Center Facility will provide a pharmacology resource for information about and techniques for studying nucleic acid components, such as bases, nucleosides, nucleotides, and oligonucleotides. This services will also include quantitation of the radioactivity associated with proteins, and Betascope and radiometric flow analytical instrumentation will be available. The analytical instruments of the Pharmacology and Analytical Center Facility are conveniently housed on the same (seventh) floor of M.D. Anderson Cancer Center in laboratories run by Director Robert Newman and co-directors William Plunkett, Timothy Madden, and David Farquhar. The equipment and analytical support to be provided by the facility are deemed critical for the success of many of the disease site- and them-specific programs proposed in this application. Formation of the Pharmacology and Analytical Center Facility will augment the ability of M.D. Anderson investigators to collaborate on studies involving pharmacologic analyses.

药理学和分析中心设施的总体目标是 提供先进的分析设备和专业知识的广泛基础 临床前和药物所需的药理学和药物化学 抗癌药物及相关疗法的临床研究。这 目标将通过重点关注三个目标来实现。首先， 药理学和分析中心设施将能够扩大 为英国大学的基础和临床科学家提供分析支持 德克萨斯MD安德森癌症中心。这种支持将包括访问 核磁共振（NMR）、液相色谱仪 (LC)/质谱 (MS)、气相色谱 (GC)、GC/MS 和高通量分析 高效液相色谱（HPLC）。支持还将包括 协助验证结构鉴定、纯化和 药物和药物代谢物稳定性的测定，以及 协助开发检测、解决身份证明问题，以及 制定验证程序。其次，科学家们运行 药理学和分析中心设施将为 研究人员寻求药代动力学和药效学信息 特定化合物和关于如何最好地利用这些信息的知识 最佳方案设计、剂量调整以提高疗效或降低疗效 毒性和类似的临床问题。最后，药理学和 分析中心设施将为以下人员提供药理学资源 有关核酸成分研究的信息和技术， 例如碱基、核苷、核苷酸和寡核苷酸。这 服务还将包括相关放射性的定量 具有蛋白质、Betascope 和辐射流量分析 仪器将可用。分析仪器 药理学和分析中心设施位于便利的位置 M.D. 安德森癌症中心同一层（七楼）的实验室由 导演罗伯特·纽曼和联合导演威廉·普朗克特、蒂莫西·马登， 和大卫·法夸尔。提供的设备和分析支持 该设施被认为对于许多疾病的成功至关重要 本申请中提出了针对特定地点和特定人群的计划。编队 药理学和分析中心设施将增强 M.D. 安德森研究人员合作开展涉及以下研究的能力 药理学分析。